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Gene Review

Slc26a2  -  solute carrier family 26 (sulfate...

Mus musculus

Synonyms: Diastrophic dysplasia protein homolog, Dtd, Dtdst, ST-OB, Solute carrier family 26 member 2, ...
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High impact information on Slc26a2

  • The NaS1 sulfate transporter maintains blood sulfate levels sufficiently high for sulfonation reactions to work effectively for drug detoxification [1].
  • In conclusion, the results of this study highlight the importance of plasma sulfate level as a key modulator of acetaminophen metabolism and suggest that individuals with reduced NaS1 sulfate transporter function would be more sensitive to hepatotoxic agents [1].
  • In this study, we describe a cDNA that encodes a sulfate transporter that was cloned as a gene induced in osteoblast precursor cells in association with osteoblastic differentiation [2].
  • The deduced amino acid sequence and proposed structure of st-ob are mostly identical to those of the human diastrophic dysplasia sulfate transporter gene product (DTDST) [2].
  • Recently, we found that the mouse DTDST gene was induced in pluripotent C3H10T1/2 cells during differentiation by bone morphogenetic protein-2 (BMP-2) [3].

Biological context of Slc26a2


Anatomical context of Slc26a2

  • The sodium-dependent sulfate transporter (NaSi-1) DNA has been recently identified from rat kidney cortex [4].

Associations of Slc26a2 with chemical compounds

  • In the present study, we have considered the contribution of cysteine and cysteine derivatives to in vivo macromolecular sulfation of cartilage by using the mouse model of DTD we have recently generated [Forlino, Piazza, Tiveron, Della Torre, Tatangelo, Bonafe, Gualeni, Romano, Pecora, Superti-Furga et al. (2005) Hum. Mol. Genet. 14, 859-871] [5].

Other interactions of Slc26a2

  • Dyastrophic dysplasia sulfate transporter (DTDST) plays an important role in proteoglycan synthesis in the extracellular matrix of bone and cartilage [3].

Analytical, diagnostic and therapeutic context of Slc26a2

  • To clarify the transcriptional regulation of the DTDST gene, we have cloned the 5'-flanking region of the mouse DTDST gene by the PCR based gene walking method [3].


  1. Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. Lee, S., Dawson, P.A., Hewavitharana, A.K., Shaw, P.N., Markovich, D. Hepatology (2006) [Pubmed]
  2. Cloning of mouse diastrophic dysplasia sulfate transporter gene induced during osteoblast differentiation by bone morphogenetic protein-2. Kobayashi, T., Sugimoto, T., Saijoh, K., Fukase, M., Chihara, K. Gene (1997) [Pubmed]
  3. Cloning and characterization of the 5'-flanking region of the mouse diastrophic dysplasia sulfate transporter gene. Kobayashi, T., Sugimoto, T., Saijoh, K., Fujii, M., Chihara, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Detection and quantitation of a sodium-dependent sulfate cotransporter (NaSi-1) by sandwich-type enzyme-linked immunosorbent assay. Sagawa, K., DuBois, D.C., Han, B., Almon, R.R., Biber, J., Murer, H., Morris, M.E. Pflugers Arch. (1998) [Pubmed]
  5. In vivo contribution of amino acid sulfur to cartilage proteoglycan sulfation. Pecora, F., Gualeni, B., Forlino, A., Superti-Furga, A., Tenni, R., Cetta, G., Rossi, A. Biochem. J. (2006) [Pubmed]
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