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Gene Review

CPA3  -  carboxypeptidase A3 (mast cell)

Homo sapiens

Synonyms: Carboxypeptidase A3, MC-CPA, Mast cell carboxypeptidase A
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High impact information on CPA3


Biological context of CPA3

  • Thus, in the carboxypeptidase gene family, MC-CPA displays a unique genealogy and several amino acid replacements in its S1' binding pocket that result in substrate specificity quite similar to bovine CPA [2].
  • We noted two consensus N-linked glycosylation sites in human MC-CPA that are not found in rat and mouse MC-CPA, or in bovine CPA; that at least one of these sites is glycosylated in vivo was verified by N-glycosidase F treatment, lentil lectin binding, and Concanavalin A-Sepharose chromatography [2].

Associations of CPA3 with chemical compounds


  1. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. Reynolds, D.S., Gurley, D.S., Austen, K.F. J. Clin. Invest. (1992) [Pubmed]
  2. Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. Natsuaki, M., Stewart, C.B., Vanderslice, P., Schwartz, L.B., Natsuaki, M., Wintroub, B.U., Rutter, W.J., Goldstein, S.M. J. Invest. Dermatol. (1992) [Pubmed]
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