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Gene Review

Cpa3  -  carboxypeptidase A3, mast cell

Mus musculus

Synonyms: Carboxypeptidase A3, MC-CPA, Mast cell carboxypeptidase A, mMC-CPA, mast cell carboxypeptidase A
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Disease relevance of Cpa3


High impact information on Cpa3


Biological context of Cpa3


Anatomical context of Cpa3


Associations of Cpa3 with chemical compounds


Other interactions of Cpa3


Analytical, diagnostic and therapeutic context of Cpa3


  1. Mouse mast cells that possess segmented/multi-lobular nuclei. Gurish, M.F., Friend, D.S., Webster, M., Ghildyal, N., Nicodemus, C.F., Stevens, R.L. Blood (1997) [Pubmed]
  2. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. Reynolds, D.S., Stevens, R.L., Gurley, D.S., Lane, W.S., Austen, K.F., Serafin, W.E. J. Biol. Chem. (1989) [Pubmed]
  3. Heparin is essential for the storage of specific granule proteases in mast cells. Humphries, D.E., Wong, G.W., Friend, D.S., Gurish, M.F., Qiu, W.T., Huang, C., Sharpe, A.H., Stevens, R.L. Nature (1999) [Pubmed]
  4. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. Gurish, M.F., Ghildyal, N., McNeil, H.P., Austen, K.F., Gillis, S., Stevens, R.L. J. Exp. Med. (1992) [Pubmed]
  5. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Reynolds, D.S., Stevens, R.L., Lane, W.S., Carr, M.H., Austen, K.F., Serafin, W.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. Reynolds, D.S., Gurley, D.S., Stevens, R.L., Sugarbaker, D.J., Austen, K.F., Serafin, W.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Abundant expression of transcription factor GATA-2 in proliferating but not in differentiated mast cells in tissues of mice: demonstration by in situ hybridization. Jippo, T., Mizuno, H., Xu, Z., Nomura, S., Yamamoto, M., Kitamura, Y. Blood (1996) [Pubmed]
  8. Loss of histochemical identity in mast cells lacking carboxypeptidase A. Feyerabend, T.B., Hausser, H., Tietz, A., Blum, C., Hellman, L., Straus, A.H., Takahashi, H.K., Morgan, E.S., Dvorak, A.M., Fehling, H.J., Rodewald, H.R. Mol. Cell. Biol. (2005) [Pubmed]
  9. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. Gurish, M.F., Nadeau, J.H., Johnson, K.R., McNeil, H.P., Grattan, K.M., Austen, K.F., Stevens, R.L. J. Biol. Chem. (1993) [Pubmed]
  10. Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. Eklund, K.K., Ghildyal, N., Austen, K.F., Friend, D.S., Schiller, V., Stevens, R.L. J. Exp. Med. (1994) [Pubmed]
  11. Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization. Jippo, T., Tsujino, K., Kim, H.M., Kim, D.K., Lee, Y.M., Nawa, Y., Kitamura, Y. Am. J. Pathol. (1997) [Pubmed]
  12. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. Lundequist, A., Tchougounova, E., Abrink, M., Pejler, G. J. Biol. Chem. (2004) [Pubmed]
  13. Proteinases of rat mast cells. Peritoneal but not intestinal mucosal mast cells express mast cell proteinase 5 and carboxypeptidase A. Befus, A.D., Chin, B., Pick, J., Evans, S., Osborn, S., Forstrom, J. J. Immunol. (1995) [Pubmed]
  14. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. Henningsson, F., Yamamoto, K., Saftig, P., Reinheckel, T., Peters, C., Knight, S.D., Pejler, G. J. Cell. Sci. (2005) [Pubmed]
  15. C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression. Yamazaki, M., Tsujimura, T., Morii, E., Isozaki, K., Onoue, H., Nomura, S., Kitamura, Y. Blood (1994) [Pubmed]
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