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Gene Review

AGPAT6  -  1-acylglycerol-3-phosphate O...

Homo sapiens

Synonyms: 1-AGP acyltransferase 6, 1-AGPAT 6, Acyl-CoA:glycerol-3-phosphate acyltransferase 4, DKFZp586M1819, GPAT4, ...
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Disease relevance of AGPAT6

  • The results of heat stress experiment demonstrate that TSARG7 expression has a relation with temperature [1].

High impact information on AGPAT6

  • Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland [2].
  • We have generated a mouse model deficient in AGPAT6, which is normally expressed at high levels in brown adipose tissue (BAT), white adipose tissue (WAT), and liver [3].
  • AGPAT6, which is predicted to contain multiple membrane-spanning helices, is found exclusively within the endoplasmic reticulum (ER) in mammalian cells [2].
  • Northern blot analysis showed that LPAAT-zeta was ubiquitously expressed in all 16 human tissues examined, with levels in the skeletal muscle, heart, and testis being relatively high and in the lung being relatively low [4].
  • The human LPAAT-zeta gene consisted of 13 exons and is positioned at chromosome 8p11.21 [4].

Biological context of AGPAT6


Anatomical context of AGPAT6


Associations of AGPAT6 with chemical compounds


  1. Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. Tan, X.J., Huang, Z.P., Li, L.Y., Nie, D.S., Zhong, C.G., Fu, J.J., Lu, G.X. Yi Chuan Xue Bao (2006) [Pubmed]
  2. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. Beigneux, A.P., Vergnes, L., Qiao, X., Quatela, S., Davis, R., Watkins, S.M., Coleman, R.A., Walzem, R.L., Philips, M., Reue, K., Young, S.G. J. Lipid Res. (2006) [Pubmed]
  3. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. Vergnes, L., Beigneux, A.P., Davis, R., Watkins, S.M., Young, S.G., Reue, K. J. Lipid Res. (2006) [Pubmed]
  4. Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. Li, D., Yu, L., Wu, H., Shan, Y., Guo, J., Dang, Y., Wei, Y., Zhao, S. J. Hum. Genet. (2003) [Pubmed]
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