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Gene Review

AAMP  -  angio-associated, migratory cell protein

Homo sapiens

Synonyms: Angio-associated migratory cell protein
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Disease relevance of AAMP


High impact information on AAMP


Biological context of AAMP

  • Both the human and yeast proteins show an unusual and almost identical arrangement of immunoglobulin type domains, WD40 repeats, a protein kinase C phosphorylation consensus site in the carboxyl region, and a positively charged amino-terminal region that in AAMP has heparin binding potential [4].

Anatomical context of AAMP

  • Polyclonal antibodies generated to P189 readily react with AAMP (52 kDa) in brain and activated T lymphocyte lysates, alpha-actinin (100 kDa) in all tissues tested, and a 23-kDa protein in skeletal muscle lysates [3].
  • Therefore, regulation of extracellular AAMP by astrocytes is hypothesized to aid in angiogenesis of the nervous system [5].

Analytical, diagnostic and therapeutic context of AAMP

  • The results of one such experimental measurement and analysis are here reported for a new design of 103palladium source, model MED3633 (North American Scientific, Inc.). By AAMP Task Group #43 recommendations, the reference material for brachytherapy dosimetry is liquid water [6].
  • Transwell cocultures of human astrocytes and BAECs increase (53%) the amount of extracellular AAMP found associated with endothelial cells [5].


  1. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. Beckner, M.E., Krutzsch, H.C., Stracke, M.L., Williams, S.T., Gallardo, J.A., Liotta, L.A. Cancer Res. (1995) [Pubmed]
  2. Analysis of gene expression in ductal carcinoma in situ of the breast. Adeyinka, A., Emberley, E., Niu, Y., Snell, L., Murphy, L.C., Sowter, H., Wykoff, C.C., Harris, A.L., Watson, P.H. Clin. Cancer Res. (2002) [Pubmed]
  3. AAMP, a newly identified protein, shares a common epitope with alpha-actinin and a fast skeletal muscle fiber protein. Beckner, M.E., Krutzsch, H.C., Klipstein, S., Williams, S.T., Maguire, J.E., Doval, M., Liotta, L.A. Exp. Cell Res. (1996) [Pubmed]
  4. AAMP, a conserved protein with immunoglobulin and WD40 domains, regulates endothelial tube formation in vitro. Beckner, M.E., Liotta, L.A. Lab. Invest. (1996) [Pubmed]
  5. Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. Beckner, M.E., Jagannathan, S., Peterson, V.A. Microvasc. Res. (2002) [Pubmed]
  6. Dosimetric characterization of a new design 103 palladium brachytherapy source. Wallace, R.E., Fan, J.J. Medical physics. (1999) [Pubmed]
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