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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Chek1  -  checkpoint kinase 1

Rattus norvegicus

Synonyms: CHK1 checkpoint homolog, Checkpoint kinase-1, Chk1, Serine/threonine-protein kinase Chk1
 
 
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High impact information on Chek1

  • Apoptosis was preceded by the activation of cell cycle checkpoints, culminating in the phosphorylation of Chk-1 and p53 [1].
  • We have isolated and characterized an isoform of protein kinase Chk1 gene from rat liver and a rat liver cDNA library by 5'-rapid amplification of cDNA ends [2].
  • The gene (Cil) contains the C-terminal region of the Chk1 gene, but the 5'-end is derived from a sequence in the intron of Chk1 preceding the C-terminal domain by differential RNA splicing [2].
  • These phenotypes of A1-5 cells are accompanied by a higher Chk1 expression and a higher phosphorylation of Cdc2 [3].
 

Analytical, diagnostic and therapeutic context of Chek1

  • We demonstrated the interaction between the kinase domain of Chk1 and Cil using a yeast two-hybrid assay and pull-down technique [2].

References

  1. Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. Santiago-Walker, A.E., Fikaris, A.J., Kao, G.D., Brown, E.J., Kazanietz, M.G., Meinkoth, J.L. J. Biol. Chem. (2005) [Pubmed]
  2. Cloning and characterization of liver-specific isoform of Chk1 gene from rat. Shann, Y.J., Hsu, M.T. J. Biol. Chem. (2001) [Pubmed]
  3. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. Hu, B., Zhou, X.Y., Wang, X., Zeng, Z.C., Iliakis, G., Wang, Y. J. Biol. Chem. (2001) [Pubmed]
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