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Gene Review

Chek1  -  checkpoint kinase 1

Mus musculus

Synonyms: C85740, CHK1 checkpoint homolog, Checkpoint kinase-1, Chk1, Serine/threonine-protein kinase Chk1, ...
 
 
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Disease relevance of Chek1

  • Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints [1].
 

High impact information on Chek1

 

Biological context of Chek1

  • These results demonstrate that mouse Hus1 is required for a specific subset of DNA damage signaling events and functions to promote genotoxin-induced Chk1 phosphorylation [4].
  • Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice [3].
  • These results may indicate that Chk1 is indispensable for cell proliferation and survival through maintaining the G(2) checkpoint in mammals [3].
  • Our results suggest that inhibition of PARP activity results in sensitization to MMS through maintenance of an ATR and Chk1-dependent S-phase checkpoint [5].
  • These results indicate that UVC induces a Chk1- and ATR or ATM-dependent checkpoint that targets both cellular and SV40 viral replication origins [1].
 

Anatomical context of Chek1

 

Associations of Chek1 with chemical compounds

  • Analysis of signaling pathways in cell extracts reveals an activation of Chk1 after treatment with MMS and 4-AN, which can be suppressed by caffeine [5].
 

Regulatory relationships of Chek1

  • These data indicate that p53 regulates Chk1 expression in a tissue-specific manner [7].
 

Other interactions of Chek1

  • Tissue-specific regulation of Chk1 expression by p53 [7].
  • We have found that inhibition of ATR and ATM kinases with caffeine or Chk1 with UCN-01, results in activation of a p38-dependent intra-S-phase checkpoint and activation of apoptosis in ES cells [6].

References

  1. Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints. Miao, H., Seiler, J.A., Burhans, W.C. J. Biol. Chem. (2003) [Pubmed]
  2. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Brown, E.J., Baltimore, D. Genes Dev. (2003) [Pubmed]
  3. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y.A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., Nakayama, K. Genes Dev. (2000) [Pubmed]
  4. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Weiss, R.S., Matsuoka, S., Elledge, S.J., Leder, P. Curr. Biol. (2002) [Pubmed]
  5. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., Wilson, S.H. J. Biol. Chem. (2005) [Pubmed]
  6. Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Jirmanova, L., Bulavin, D.V., Fornace, A.J. Cell Cycle (2005) [Pubmed]
  7. Tissue-specific regulation of Chk1 expression by p53. Cheung, K.J., Li, G. Exp. Mol. Pathol. (2001) [Pubmed]
 
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