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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

chk-1  -  Protein CHK-1

Caenorhabditis elegans

 
 
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High impact information on chk-1

  • How anterior-posterior (A-P) polarity cues control this asynchrony remains to be elucidated.RESULTS: We establish that early C. elegans embryos possess a hitherto unrecognized DNA replication checkpoint that relies on the PI-3-like kinase atl-1 and the kinase chk-1 [1].
  • As expected, disruption of chk-1 by RNAi eliminated the DNA damage checkpoint response in C. elegans [2].
  • In addition, we revealed that chk-1 was predominantly expressed during embryogenesis and in the postembryonic germline [2].
  • More specifically, disruption of chk-1 expression resulted in embryo lethality, which was attributed to a defect in an intrinsic S-M checkpoint hence causing premature entry into M-phase [2].
 

Biological context of chk-1

References

  1. Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Brauchle, M., Baumer, K., Gönczy, P. Curr. Biol. (2003) [Pubmed]
  2. chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis. Kalogeropoulos, N., Christoforou, C., Green, A.J., Gill, S., Ashcroft, N.R. Cell Cycle (2004) [Pubmed]
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