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Gene Review

Foxf2  -  forkhead box F2

Mus musculus

Synonyms: FREAC2, Fkh20, Forkhead box protein F2, LUN, Lun, ...
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Disease relevance of Foxf2

  • Inactivation of both Foxf2 alleles, or one allele each of Foxf1 and Foxf2, cause a range of defects, including megacolon, colorectal muscle hypoplasia and agangliosis [1].
  • Mice lacking the Foxf2 gene were found to develop cleft palate and an abnormal tongue [2].

High impact information on Foxf2


Biological context of Foxf2

  • To investigate if the differences in mutant phenotype can be attributed to nonoverlapping expression patterns or if distinct functions of the encoded proteins have to be inferred, we analyzed the early embryonic expression of Foxf2 and compared it with that of the better investigated Foxf1 [3].

Anatomical context of Foxf2


Analytical, diagnostic and therapeutic context of Foxf2


  1. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B.R., Miura, N., Carlsson, P. Development (2006) [Pubmed]
  2. Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate. Wang, T., Tamakoshi, T., Uezato, T., Shu, F., Kanzaki-Kato, N., Fu, Y., Koseki, H., Yoshida, N., Sugiyama, T., Miura, N. Dev. Biol. (2003) [Pubmed]
  3. Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes. Ormestad, M., Astorga, J., Carlsson, P. Dev. Dyn. (2004) [Pubmed]
  4. Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions. Aitola, M., Carlsson, P., Mahlapuu, M., Enerbäck, S., Pelto-Huikko, M. Dev. Dyn. (2000) [Pubmed]
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