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traT  -  conjugal transfer surface exclusion...

Escherichia coli

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Disease relevance of traT


High impact information on traT

  • The product of the F sex factor traT surface exclusion gene is a lipoprotein [3].
  • The product of the Escherichia coli sex factor F traT gene (TraTp), an outer membrane protein of Mr = 25,000, is covalently modified in vivo by the addition of glycerol and fatty acids [3].
  • Being a secreted protein, TraTp is made from a signal sequence containing precursor, and glycerol and fatty acids can be detected in both the precursor and mature (processed) species of TraTp [3].
  • Consistent with this result, and as would be expected for a bacterial lipoprotein, the novel amino acid glycerylcysteine can be detected in purified TraTp [3].
  • Diglyceride modification of the Cys residue at the site of signal sequence cleavage probably precedes and is a prerequisite for processing of the TraTp signal sequence [3].

Chemical compound and disease context of traT

  • In both intestinal and blood E. coli isolates, the traT, iss, and aerobactin receptor genes were present at similar frequencies, but the frequency of the aerobactin synthesis genes was significantly different [4].

Biological context of traT


Associations of traT with chemical compounds

  • Most isolates (72%) were positive for traT, and a majority produced colicin V and aerobactin (92 and 82%, respectively) [8].

Other interactions of traT

  • Ten VFs were less prevalent (p <0.05) in the ESBL isolates than the susceptible E. coli, while iutA and traT were more prevalent in ESBL isolates (p <0.05) [9].
  • Surface exclusion genes traS and traT of the F sex factor of Escherichia coli K-12. Determination of the nucleotide sequence and promoter and terminator activities [1].
  • Among the colicin V-producing isolates, the iss, traT, and iu genes were present in 95.5, 86.4, and 90.9% of the blood isolates and in only 68.8, 43.8, and 81.3% of the intestinal isolates, respectively [4].


  1. Surface exclusion genes traS and traT of the F sex factor of Escherichia coli K-12. Determination of the nucleotide sequence and promoter and terminator activities. Jalajakumari, M.B., Guidolin, A., Buhk, H.J., Manning, P.A., Ham, L.M., Hodgson, A.L., Cheah, K.C., Skurray, R.A. J. Mol. Biol. (1987) [Pubmed]
  2. The role of the traT gene of the Salmonella typhimurium virulence plasmid for serum resistance and growth within liver macrophages. Rhen, M., Sukupolvi, S. Microb. Pathog. (1988) [Pubmed]
  3. The product of the F sex factor traT surface exclusion gene is a lipoprotein. Perumal, N.B., Minkley, E.G. J. Biol. Chem. (1984) [Pubmed]
  4. Virulence-related genes in ColV plasmids of Escherichia coli isolated from human blood and intestines. Fernandez-Beros, M.E., Kissel, V., Lior, H., Cabello, F.C. J. Clin. Microbiol. (1990) [Pubmed]
  5. Nucleotide sequence of the traD region in the Escherichia coli F sex factor. Jalajakumari, M.B., Manning, P.A. Gene (1989) [Pubmed]
  6. Association of K-1 capsule, smooth lipopolysaccharides, traT gene, and Colicin V production with complement resistance and virulence of avian Escherichia coli. Wooley, R.E., Nolan, L.K., Brown, J., Gibbs, P.S., Giddings, C.W., Turner, K.S. Avian Dis. (1993) [Pubmed]
  7. Transcriptional analysis of the F plasmid surface exclusion region: mapping of traS, traT, and traD transcripts. Ham, L.M., Cram, D., Skurray, R. Plasmid (1989) [Pubmed]
  8. Escherichia coli cellulitis in broiler chickens: clonal relationships among strains and analysis of virulence-associated factors of isolates from diseased birds. Ngeleka, M., Kwaga, J.K., White, D.G., Whittam, T.S., Riddell, C., Goodhope, R., Potter, A.A., Allan, B. Infect. Immun. (1996) [Pubmed]
  9. Virulence genotype and nematode-killing properties of extra-intestinal Escherichia coli producing CTX-M beta-lactamases. Lavigne, J.P., Blanc-Potard, A.B., Bourg, G., Moreau, J., Chanal, C., Bouziges, N., O'callaghan, D., Sotto, A. Clin. Microbiol. Infect. (2006) [Pubmed]
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