Disease relevance of Sex Factors

• Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes [1].
• Tenderness thresholds of tender points were coded and analyzed using repeated measures ANOVA, for factors sex, normal/fibromyalgia, and side, rater, and time 1/time 2 [2].
• Vibrio cholerae hybrid sex factor that contains ampicillin transposon Tn1 [3].
• However, transconjugants were unable to further transfer toluene genes to other recipients unless Pseudomonas sex factor R68.45 was present in trans [4].
• The homologous lactococcal conjugative elements pRS01 and the sex factor of Lactococcus lactis strain 712 both contain a Group II intron within a gene believed to encode a conjugative relaxase enzyme [5].

Psychiatry related information on Sex Factors

• This supports the significance of the sex factor in the genetic transmission of affective disorders, and a possible involvement of COMT activity changes in the pathogenesis of such disorders in women [6].

High impact information on Sex Factors

• These findings demonstrate that sex factors play a fundamental role in the regulation of cholesterol metabolism in the human liver [7].
• A lipidated carboxyl-terminal cysteine residue is also found in sequence-related yeast sex factors, and in at least two cases, the alpha-carboxyl group is also methyl esterified [8].
• New perspectives on growth factor-sex steroid interaction in the prostate [9].
• Gene-disruption experiments were used to demonstrate that this mobA gene was essential for sex-factor transfer and this suggests that intron splicing is a necessary part of the conjugation process [10].
• Analysis of 23 independently derived enlarged lactose plasmids revealed that the sex factor DNA present in cointegrates varied in size [11].

Chemical compound and disease context of Sex Factors

• 6. None of the factors sex, age, treatment duration, total aminoglycoside doses or first serum creatinine concentration, was found to be associated with hearing loss [12].

Biological context of Sex Factors

• High-frequency conjugation of the lactose plasmid pLP712 is associated with a constitutive cell aggregation phenotype and is facilitated by cointegration with a sex factor [11].
• A possible role for the traD cistron of sex factor F in the intracellular development of MS2 is suggested [13].
• Control of cell division by sex factor F in Escherichia coli. III. Participation of the groES (mopB) gene of the host bacteria [14].
• An Hfr strain (PB15) that carries a duplicated copy of the galactose operon genes flanking the integrated sex factor is unusually stable since it does not show excision of the repeated deoxyribonucleic acid segment [15].

Associations of Sex Factors with chemical compounds

• Kanamycin resistance could be transferred from one strain of P. denitrificans to another, thus opening up the possibility of using R68.45 as a sex factor in P. denitrificans [16].
• Deletion mutations that eliminate the right-hand galactose genes, the sex factor, and some of the left-hand operon have been isolated [15].
• Genetic analysis shows the plasmid pWS7 is in fact, a sex-factor which is curable with acridine orange [17].
• Sex factors also play a major role in the pathogenesis based on the physiologic effects of estrogen in promoting immunologic hyperactivity [18].
• Sex factors and plasma levels of oxytetracycline (OTC) in rats [19].

Gene context of Sex Factors

• Regulatory mechanisms in expression of the traY-I operon of sex factor plasmid R100: involvement of traJ and traY gene products [20].
• Control of segregation of chromosomal DNA by sex factor F in Escherichia coli. Mutants of DNA gyrase subunit A suppress letD (ccdB) product growth inhibition [21].
• If two of the neoplasms are present, a presumptive diagnosis of the "triad" can be made, particularly if age and sex factors are supportive [22].
• When HDL cholesterol was controlled for in a multivariate regression analysis, the sex factor was not significant [23].
• Female sex determination in the pill bug Armadillidium vulgare is frequently under the control of feminizing parasitic sex factors (PSF) [24].

References