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Gene Review:

EME1 - essential meiotic structure-specific...

Homo sapiens

Synonyms: Crossover junction endonuclease EME1, FLJ31364, MMS4, MMS4 homolog, MMS4L, ...

Abraham, J. et al., Ciccia, A. et al., Oğrünç, M. et al., Möller, M.R. et al., Hiyama, T. et al.

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High impact information on EME1

Unlike Blm-deficient ES cells, increased SCE was seen only following induced DNA damage in Eme1-deficient cells [1].
Most importantly, Eme1 deficiency led to spontaneous genomic instability [1].
These results reveal that mammalian Eme1 plays a key role in DNA repair and the maintenance of genome integrity [1].
Yeast and human Eme1 protein, in complex with Mus81, constitute an endonuclease that cleaves branched DNA structures, especially those arising during stalled DNA replication [1].
Mammalian Eme1 is not required for the resolution of DNA intermediates that arise during homologous recombination processes such as gene targeting, gene conversion and sister chromatid exchange (SCE) [1].

Biological context of EME1

Haploinsufficiency of Mus81 or Eme1 also causes similar phenotypes [2].

Associations of EME1 with chemical compounds

The method is reproducible (cocaine, CV = 8%; BZE, CV = 14%) and the detection limit for cocaine and BZE was 0.1 ng/mg, for EME 1 ng/mg [3].

Physical interactions of EME1

MUS81 also has a binding partner named Mms4 in Saccharomyces cerevisiae and Eme1 in Schizosaccharomyces pombe, but no such partner was identified in human cells [4].

Other interactions of EME1

In fission yeast, the Mus81-Eme1 endonuclease complex (Mus81-Mms4 in Saccharomyces cerevisiae) has been implicated in the processing of aberrant replication intermediates [5].

References

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. Abraham, J., Lemmers, B., Hande, M.P., Moynahan, M.E., Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A.K., McPherson, P., Shehabeldin, A., Laister, R., Arrowsmith, C., Kanaar, R., West, S.C., Jasin, M., Hakem, R. EMBO J. (2003) [Pubmed]
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Hiyama, T., Katsura, M., Yoshihara, T., Ishida, M., Kinomura, A., Tonda, T., Asahara, T., Miyagawa, K. Nucleic Acids Res. (2006) [Pubmed]
Identification and quantitation of cocaine and its metabolites, benzoylecgonine and ecgonine methyl ester, in hair of Bolivian coca chewers by gas chromatography/mass spectrometry. Möller, M.R., Fey, P., Rimbach, S. Journal of analytical toxicology. (1992) [Pubmed]
Identification and characterization of human MUS81-MMS4 structure-specific endonuclease. Oğrünç, M., Sancar, A. J. Biol. Chem. (2003) [Pubmed]
Identification and characterization of the human mus81-eme1 endonuclease. Ciccia, A., Constantinou, A., West, S.C. J. Biol. Chem. (2003) [Pubmed]

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AgaP_AGAP002302	Anopheles gambiae str. PEST
EME1	Canis lupus familiaris
eme1	Danio rerio
mms4	Drosophila melanogaster
EME1	Gallus gallus
Eme1	Mus musculus
EME1	Pan troglodytes
Eme1	Rattus norvegicus
eme1	Xenopus (Silurana) tropicalis

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