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Gene Review

EME1  -  essential meiotic structure-specific...

Homo sapiens

Synonyms: Crossover junction endonuclease EME1, FLJ31364, MMS4, MMS4 homolog, MMS4L, ...
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High impact information on EME1


Biological context of EME1


Associations of EME1 with chemical compounds

  • The method is reproducible (cocaine, CV = 8%; BZE, CV = 14%) and the detection limit for cocaine and BZE was 0.1 ng/mg, for EME 1 ng/mg [3].

Physical interactions of EME1


Other interactions of EME1


  1. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. Abraham, J., Lemmers, B., Hande, M.P., Moynahan, M.E., Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A.K., McPherson, P., Shehabeldin, A., Laister, R., Arrowsmith, C., Kanaar, R., West, S.C., Jasin, M., Hakem, R. EMBO J. (2003) [Pubmed]
  2. Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Hiyama, T., Katsura, M., Yoshihara, T., Ishida, M., Kinomura, A., Tonda, T., Asahara, T., Miyagawa, K. Nucleic Acids Res. (2006) [Pubmed]
  3. Identification and quantitation of cocaine and its metabolites, benzoylecgonine and ecgonine methyl ester, in hair of Bolivian coca chewers by gas chromatography/mass spectrometry. Möller, M.R., Fey, P., Rimbach, S. Journal of analytical toxicology. (1992) [Pubmed]
  4. Identification and characterization of human MUS81-MMS4 structure-specific endonuclease. Oğrünç, M., Sancar, A. J. Biol. Chem. (2003) [Pubmed]
  5. Identification and characterization of the human mus81-eme1 endonuclease. Ciccia, A., Constantinou, A., West, S.C. J. Biol. Chem. (2003) [Pubmed]
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