The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gtf2i  -  general transcription factor II I

Mus musculus

Synonyms: 6030441I21Rik, BAP-135, BTK-associated protein 135, Bap135, Bruton tyrosine kinase-associated protein 135, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gtf2i


High impact information on Gtf2i

  • Both the initiator binding protein, TFII-I, and SP1 have been found to interact physically with components of the TFIID complex [2].
  • The Spin peptide, when complexed with Dd, also activated the T cell [3].
  • These data suggest that Bright functions as a three-component protein complex in the immunoglobulin locus and tie together previous data indicating important roles for Btk and TFII-I in B lymphocytes [4].
  • Similarly, Xenopus embryos with endogenous TFII-I expression downregulated by injection of TFII-I-specific antisense oligonucleotides exhibit decreased Gsc expression [5].
  • We also identify a DICE-interacting factor: a TFII-I-related protein known as BEN (also termed Mus-TRD1 and WBSCR11) [6].

Biological context of Gtf2i


Anatomical context of Gtf2i

  • Using RT-PCR, we detected Gtf2i and Gtf2ird1 mRNA transcripts in unfertilized oocytes, which indicates the maternal expression of these genes [9].
  • Moreover, inhibition of TFII-I function in a B-cell line resulted in decreased heavy-chain transcript levels [4].

Other interactions of Gtf2i


Analytical, diagnostic and therapeutic context of Gtf2i

  • Gtf2i transcript is detectable in ES cells by RT-PCR and on Northern blots of tissues from 7-dpc embryos [1].
  • Sequence analysis of the proximal promoter region revealed several potential regulatory elements; these include the recognition elements of Sp1, Nkx, CP2, E2A, SIF (SIS-inducible factor), TFII-I and cAMP-responsive element (CRE), but no TATA sequences [10].


  1. A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region. Wang, Y.K., Pérez-Jurado, L.A., Francke, U. Genomics (1998) [Pubmed]
  2. Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure. Ham, J., Steger, G., Yaniv, M. EMBO J. (1994) [Pubmed]
  3. Using a baculovirus display library to identify MHC class I mimotopes. Wang, Y., Rubtsov, A., Heiser, R., White, J., Crawford, F., Marrack, P., Kappler, J.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Rajaiya, J., Nixon, J.C., Ayers, N., Desgranges, Z.P., Roy, A.L., Webb, C.F. Mol. Cell. Biol. (2006) [Pubmed]
  5. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Ku, M., Sokol, S.Y., Wu, J., Tussie-Luna, M.I., Roy, A.L., Hata, A. Mol. Cell. Biol. (2005) [Pubmed]
  6. Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. Tantin, D., Tussie-Luna, M.I., Roy, A.L., Sharp, P.A. J. Biol. Chem. (2004) [Pubmed]
  7. Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region. Bayarsaihan, D., Dunai, J., Greally, J.M., Kawasaki, K., Sumiyama, K., Enkhmandakh, B., Shimizu, N., Ruddle, F.H. Genomics (2002) [Pubmed]
  8. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Danoff, S.K., Taylor, H.E., Blackshaw, S., Desiderio, S. Neuroscience (2004) [Pubmed]
  9. The early embryonic expression of TFII-I during mouse preimplantation development. Enkhmandakh, B., Bitchevaia, N., Ruddle, F., Bayarsaihan, D. Gene Expr. Patterns (2004) [Pubmed]
  10. Genomic organization, chromosomal mapping and promoter analysis of the mouse selenocysteine tRNA gene transcription-activating factor (mStaf) gene. Adachi, K., Katsuyama, M., Song, S., Oka, T. Biochem. J. (2000) [Pubmed]
WikiGenes - Universities