High impact information on Gzmk

• Granzyme K (GzmK) belongs to a family of trypsin-like serine proteases localized in electron dense cytoplasmic granules of activated natural killer and cytotoxic T-cells [1].
• Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes [2].
• We conclude that GzmK expressed by GzmA-deficient T cells accounts for the remaining Z-Lys-SBzl activity [3].
• A cDNA for a novel serine protease, termed brain type granzyme K (B-GRK) was cloned from the mouse brain [4].
• The recombinant fusion protein was detected in the neuro2a cells transfected with a plasmid containing B-GRK sequence [4].

Anatomical context of Gzmk

• The mRNA for B-GRK/GRK was detected in cerebral cortex, hippocampus and diencephalon of the mouse brain [4].
• In situ hybridization for B-GRK/GRK revealed that several regions in the forebrain and hypothalamus express the mRNA [4].

Other interactions of Gzmk

• Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice [3].

Analytical, diagnostic and therapeutic context of Gzmk

• Genomic Southern and PCR analysis of the gene suggests B-GRK is the alternative transcription form of GRK [4].

References