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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

H2-Q4  -  histocompatibility 2, Q region locus 4

Mus musculus

Synonyms: H-2Q4, H2-Gs10, Qa-4, Qa4, Qat-4, ...
 
 
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High impact information on H2-Q4

  • Thus, Qat-4 is expressed on 70%, and Qat-5 on 30% of splenic and lymph node T cells, Qat-4 is also found on the majority of Ig- cells from athymic nude mice [1].
  • The results were similar whether or not T cells were removed from the assay marrow by treatment with antibodies Ly-1.1, Ly-2.2, and Qa4 plus C.(ABSTRACT TRUNCATED AT 400 WORDS)[2]
  • Q4, the gene encoding the Qb-1 antigen, is transcribed in a wide variety of tissues, unlike many other non-classical class I genes [3].
 

Biological context of H2-Q4

  • L-cells transfected with these genes did not express class I genes reacting with alloantisera or monoclonal antibodies against Qa2, Qa4 or TL differentiation antigens [4].
 

Anatomical context of H2-Q4

  • Two new lymphocyte antigens, provisionally designated Qat-4 and Qat-5 have been identified with two different hybridoma-derived, monoclonal AKR antiC57BL/6 antibodies [1].
 

Other interactions of H2-Q4

  • Qat-4 and Qat-5 antigens which do not seem to be identical with Qa-2,3 or TL antigens are absent from Ig/ lymphocytes and thymocytes [1].
 

Analytical, diagnostic and therapeutic context of H2-Q4

References

  1. Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. Hämmerling, G.J., Hämmerling, U., Flaherty, L. J. Exp. Med. (1979) [Pubmed]
  2. Lactoferrin acts on I-A and I-E/C antigen+ subpopulations of mouse peritoneal macrophages in the absence of T lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro. Broxmeyer, H.E., Platzer, E. J. Immunol. (1984) [Pubmed]
  3. Expression of a MHC non-classical class I gene, Q4, is similar to a classical class I gene, Dp. Badley, J.E., Frelinger, J.A. Eur. J. Immunogenet. (1991) [Pubmed]
  4. Identification of murine H-2Db histocompatibility antigens in cells transfected with cloned H-2 genes. Schmidt, W., Ferluga, J., Festenstein, H., Weiss, E. Mol. Immunol. (1985) [Pubmed]
  5. Sequence of the mouse Q4 class I gene and characterization of the gene product. Robinson, P.J., Bevec, D., Mellor, A.L., Weiss, E.H. Immunogenetics (1988) [Pubmed]
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