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Gene Review

H3f3b  -  H3 histone, family 3B

Mus musculus

Synonyms: 9430068D06Rik, H3.3B
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High impact information on H3f3b

  • We show here that the three polyadenylated mRNAs produced from the H3.3B gene, as well as the single mRNA produced from the related H3.3A gene, are coordinately induced during the first few hours of MEL cell differentiation and subsequently down regulated as cells undergo terminal differentiation [1].
  • Using probes specific for these two different genes we show by RNase protection analysis and by nonradioactive in situ hybridization with testis sections that H3.3A mRNA is present in pre- and postmeiotic cells, whereas expression of the H3.3B gene is essentially restricted to cells of the meiotic prophase [2].

Biological context of H3f3b


  1. Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation. Krimer, D.B., Cheng, G., Skoultchi, A.I. Nucleic Acids Res. (1993) [Pubmed]
  2. Differential expression of the murine histone genes H3.3A and H3.3B. Bramlage, B., Kosciessa, U., Doenecke, D. Differentiation (1997) [Pubmed]
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