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Gene Review

Htr5a  -  5-hydroxytryptamine (serotonin) receptor 5A

Mus musculus

Synonyms: 5-HT-5, 5-HT-5A, 5-HT5A, 5-hydroxytryptamine receptor 5A, 5ht5a, ...
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Disease relevance of Htr5a

  • 5-HT3 receptors in outside-out patches of N1E-115 neuroblastoma cells: basic properties and effects of pentobarbital [1].
  • These results suggest that 5-HT released from mast cells is partly involved in the development of capsaicin-induced mouse ear edema via 5-HT2 receptors in the ear skin [2].

High impact information on Htr5a

  • Pharmacological studies suggested that release of arachidonic acid and inositol phosphates was mediated by a type 2 5-HT (5-HT2) receptor [3].
  • 5-HT-stimulated release of arachidonic acid was also detected in cortical neurons, which contain high levels of 5-HT2 receptors, but not striatum, spinal cord, or cerebellar granule cells, which have very low levels or are devoid of 5-HT2 receptors [3].
  • Amino acid sequence comparisons revealed that this receptor was a close relative of the previously identified 5-HT5 receptor but was distant from all other 5-HT receptor subtypes; we therefore named it 5-HT5B [4].
  • A fast solution exchange system (Dilger and Brett, 1990; Biophysics Journal 57: 723-731) with an exchange rate < 1 msec was used to study 5-HT3 (5-HT; 5-hydroxytryptamine) receptor-mediated currents in superfused outside-out patches of N1E-115 mouse neuroblastoma cells [1].
  • The results obtained in this model with pentobarbital are compatible with the suggestion that the inhibitory action of pentobarbital on 5-HT3 receptors is dependent on the agonist-activated (open) channel [1].

Chemical compound and disease context of Htr5a


Associations of Htr5a with chemical compounds


  1. 5-HT3 receptors in outside-out patches of N1E-115 neuroblastoma cells: basic properties and effects of pentobarbital. Barann, M., Göthert, M., Bönisch, H., Dybek, A., Urban, B.W. Neuropharmacology (1997) [Pubmed]
  2. Participation of serotonin in capsaicin-induced mouse ear edema. Inoue, H., Nagata, N., Koshihara, Y. Jpn. J. Pharmacol. (1995) [Pubmed]
  3. Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Felder, C.C., Kanterman, R.Y., Ma, A.L., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Matthes, H., Boschert, U., Amlaiky, N., Grailhe, R., Plassat, J.L., Muscatelli, F., Mattei, M.G., Hen, R. Mol. Pharmacol. (1993) [Pubmed]
  5. Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Danielson, P.E., Watson, J.B., Gerendasy, D.D., Erlander, M.G., Lovenberg, T.W., de Lecea, L., Sutcliffe, J.G., Frankel, W.N. Genomics (1994) [Pubmed]
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