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Gene Review

Elavl4  -  ELAV (embryonic lethal, abnormal vision,...

Mus musculus

Synonyms: ELAV-like protein 4, Elav, Hu-antigen D, HuD, Hud, ...
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Disease relevance of Elavl4


High impact information on Elavl4

  • We have isolated the gene that encodes the neural-specific RNA binding protein HuD in the mouse (Elavl4), and have mapped its location to the mid-distal region of chromosome 4, close to the neurological mutant clasper [2].
  • Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4 [2].
  • Elavl4 mRNAs are alternatively spliced in the region between RBDs 2 and 3 due to the variable use of two micro-exons, and RNase protection analysis indicates that two of four possible splice variants are the predominant isoforms expressed in the central nervous system [2].
  • The coding region of the Elavl4 gene covers approximately 44 kb; the first two RNA binding domains (RBDs) that are homologous to the two RBDs found in the Drosophila sex-lethal gene are each encoded in two exons, whereas the third RBD is encoded in a single exon [2].
  • These data suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome [3].


  1. DNA vaccination against HuD antigen elicits antitumor activity in a small-cell lung cancer murine model. Ohwada, A., Nagaoka, I., Takahashi, F., Tominaga, S., Fukuchi, Y. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  2. Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4. Inman, M.V., Levy, S., Mock, B.A., Owens, G.C. Gene (1998) [Pubmed]
  3. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Fletcher, C.F., Okano, H.J., Gilbert, D.J., Yang, Y., Yang, C., Copeland, N.G., Jenkins, N.A., Darnell, R.B. Genomics (1997) [Pubmed]
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