The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

Ifi204  -  interferon activated gene 204

Mus musculus

Synonyms: Ifi-204, Ifi16, Interferon-activable protein 204, Interferon-inducible protein p204, p204
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Ifi204

  • Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster [1].
  • This increase is probably due to the activation of the gene encoding 204 (Ifi204) by Smad transcription factor, including Smad1, -4, and -5 [2].
  • Moreover, the role of p204 in the control of cell growth in vivo was investigated by generating transgenic mice in which the Ifi 204 gene was constitutively expressed in all tissues [3].
  • The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells [4].
  • The murine homolog of the HIN 200 family, Ifi 204, is constitutively expressed in myeloid cells and selectively induced in the monocyte/macrophage lineage [5].
 

Associations of Ifi204 with chemical compounds

  • Ras did not promote phosphorylation or translocation to the cytoplasm of mutated p204 in which serine 179 was replaced by alanine. p204 overexpression inhibited the anchorage-independent proliferation of cells expressing Ras(Q61L) oncoprotein [6].
 

Biological context of Ifi204

  • The presence of an additional transcribed region in intron 4 of Ifi203a and b suggests the possibility of alternative splicing, and a spliced variant of the Ifi204' mRNA exhibits 91% sequence identity with a related but unmapped D3 mRNA [7].
  • These results demonstrate that MCMV may exploit the Ifi204 gene to regulate the cell cycle and enhance its DNA synthesis [8].
  • The activity of a reporter gene driven by the mouse Ifi204 promoter induced following virus infection showed that this increase was due to transcriptional activation [8].
 

Anatomical context of Ifi204

  • The mouse interferon-inducible gene Ifi204 product interacts with the Tpr protein, a component of the nuclear pore complex [9].
 

Other interactions of Ifi204

References

  1. Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster. Choubey, D., Lengyel, P. J. Cell Biol. (1992) [Pubmed]
  2. The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. Liu, C.J., Chang, E., Yu, J., Carlson, C.S., Prazak, L., Yu, X.P., Ding, B., Lengyel, P., Di Cesare, P.E. J. Biol. Chem. (2005) [Pubmed]
  3. Inhibition of cell proliferation by the interferon-inducible 204 gene, a member of the Ifi 200 cluster. Lembo, M., Sacchi, C., Zappador, C., Bellomo, G., Gaboli, M., Pandolfi, P.P., Gariglio, M., Landolfo, S. Oncogene (1998) [Pubmed]
  4. The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells. Dauffy, J., Mouchiroud, G., Bourette, R.P. J. Leukoc. Biol. (2006) [Pubmed]
  5. The murine homolog of the HIN 200 family, Ifi 204, is constitutively expressed in myeloid cells and selectively induced in the monocyte/macrophage lineage. Gariglio, M., De Andrea, M., Lembo, M., Ravotto, M., Zappador, C., Valente, G., Landolfo, S. J. Leukoc. Biol. (1998) [Pubmed]
  6. p204 protein is a novel modulator of ras activity. Ding, B., Lengyel, P. J. Biol. Chem. (2008) [Pubmed]
  7. The mouse Ifi200 gene cluster: genomic sequence, analysis, and comparison with the human HIN-200 gene cluster. Deschamps, S., Meyer, J., Chatterjee, G., Wang, H., Lengyel, P., Roe, B.A. Genomics (2003) [Pubmed]
  8. The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication. Rolle, S., De Andrea, M., Gioia, D., Lembo, D., Hertel, L., Landolfo, S., Gariglio, M. Virology (2001) [Pubmed]
  9. The mouse interferon-inducible gene Ifi204 product interacts with the Tpr protein, a component of the nuclear pore complex. De Andrea, M., Zannetti, C., Noris, E., Gariglio, M., Azzimonti, B., Landolfo, S. J. Interferon Cytokine Res. (2002) [Pubmed]
  10. Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and alpha-spectrin on mouse chromosome 1. Kingsmore, S.F., Snoddy, J., Choubey, D., Lengyel, P., Seldin, M.F. Immunogenetics (1989) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities