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Gene Review

ZFPM1  -  zinc finger protein, FOG family member 1

Homo sapiens

Synonyms: FOG, FOG-1, FOG1, Friend of GATA 1, Friend of GATA protein 1, ...
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Disease relevance of ZFPM1


High impact information on ZFPM1

  • These results indicate that FOG-1 is a determinant of GATA factor target gene sensitivity by either facilitating or opposing chromatin occupancy [4].
  • Thus, FOG-1 facilitates chromatin occupancy by GATA-1 at sites bound by GATA-2 [5].
  • However, at DNase I-hypersensitive site (HS)3 of the beta-globin locus control region, GATA-1-induced histone acetylation was FOG-1-independent [6].
  • In contrast, abrogation of GATA1-FOG-1 interaction leads to loss of differentiation, but growth of blocked immature megakaryocytes is controlled [7].
  • Previous studies of synthetic and naturally occurring mutant GATA1 molecules demonstrate that DNA-binding and interaction with the essential GATA1 cofactor FOG-1 (via the N-terminal finger) are required for gene expression in terminally differentiating megakaryocytes and for platelet production [7].

Biological context of ZFPM1


Physical interactions of ZFPM1


Regulatory relationships of ZFPM1

  • The mechanisms by which FOG-1 regulates GATA-1 function are unknown [6].

Other interactions of ZFPM1


  1. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Yu, C., Niakan, K.K., Matsushita, M., Stamatoyannopoulos, G., Orkin, S.H., Raskind, W.H. Blood (2002) [Pubmed]
  2. Effects of the R216Q mutation of GATA-1 on erythropoiesis and megakaryocytopoiesis. Balduini, C.L., Pecci, A., Loffredo, G., Izzo, P., Noris, P., Grosso, M., Bergamaschi, G., Rosti, V., Magrini, U., Ceresa, I.F., Conti, V., Poggi, V., Savoia, A. Thromb. Haemost. (2004) [Pubmed]
  3. Absence of mutations in the key megakaryocyte transcriptional regulator FOG-1 in patients with idiopathic myelofibrosis. Fisher, C., Steensma, D., Janmohamed, R., Kaczmarski, R., Reilly, J.T., Vyas, P. Br. J. Haematol. (2004) [Pubmed]
  4. Differential sensitivities of transcription factor target genes underlie cell type-specific gene expression profiles. Johnson, K.D., Kim, S.I., Bresnick, E.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Pal, S., Cantor, A.B., Johnson, K.D., Moran, T.B., Boyer, M.E., Orkin, S.H., Bresnick, E.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Context-dependent regulation of GATA-1 by friend of GATA-1. Letting, D.L., Chen, Y.Y., Rakowski, C., Reedy, S., Blobel, G.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1. Kuhl, C., Atzberger, A., Iborra, F., Nieswandt, B., Porcher, C., Vyas, P. Mol. Cell. Biol. (2005) [Pubmed]
  8. Global regulation of erythroid gene expression by transcription factor GATA-1. Welch, J.J., Watts, J.A., Vakoc, C.R., Yao, Y., Wang, H., Hardison, R.C., Blobel, G.A., Chodosh, L.A., Weiss, M.J. Blood (2004) [Pubmed]
  9. The role of cytokines and transcription factors in megakaryocytopoiesis. Yang, M., Li, K. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2002) [Pubmed]
  10. Transcriptional control networks of cell differentiation: insights from helper T lymphocytes. Mariani, L., Löhning, M., Radbruch, A., Höfer, T. Prog. Biophys. Mol. Biol. (2004) [Pubmed]
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