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Gene Review

Zfpm1  -  zinc finger protein, multitype 1

Mus musculus

Synonyms: FOG, FOG-1, Fog, Fog1, Friend of GATA 1, ...
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Disease relevance of Zfpm1


High impact information on Zfpm1

  • This highly conserved valine is necessary for interaction of the amino-terminal zinc finger of GATA-1 with its essential cofactor, FOG-1 (for friend of GATA-1; refs 9-12) [4].
  • GATA-1 upregulated critical MegE-related transcription factors such as FOG-1 and GATA-2 in lymphoid and GM progenitors, and their MegE development did not require "permissive" erythropoietin signals [5].
  • We show that FOG-1 can repress GATA-3-dependent activation of the IL-5 promoter in T cells [6].
  • Also, FOG-1 overexpression during primary activation of naive T cells inhibited Th2 development in CD4+ T cells [6].
  • FOG-1 overexpression repressed development of Th2 cells from naive T cells, but did not reverse the phenotype of fully committed Th2 cells [6].

Biological context of Zfpm1


Anatomical context of Zfpm1


Physical interactions of Zfpm1


Regulatory relationships of Zfpm1


Other interactions of Zfpm1

  • In contrast, conditional inactivation of FOG-1 in endothelial-derived tissues by means of Tie-2-expressed Cre recapitulates the rescue-knockout defects [1].
  • The FOG proteins (FOG-1 and FOG-2) can act as either enhancers or repressors of GATA transcriptional activity, depending on the cell and promoter context [14].
  • As such, we propose that FOG-1 may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell [13].
  • Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo [12].
  • We identify endocardial cushion expression of the transcription factor Fog1, and we demonstrate active Wnt/beta-catenin signaling in developing endocardial cushions suggesting pathways that have not been previously appreciated to participate in cardiac valve formation [15].

Analytical, diagnostic and therapeutic context of Zfpm1


  1. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Katz, S.G., Williams, A., Yang, J., Fujiwara, Y., Tsang, A.P., Epstein, J.A., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Muntean, A.G., Crispino, J.D. Blood (2005) [Pubmed]
  3. Fog1 is required for cardiac looping in zebrafish. Walton, R.Z., Bruce, A.E., Olivey, H.E., Najib, K., Johnson, V., Earley, J.U., Ho, R.K., Svensson, E.C. Dev. Biol. (2006) [Pubmed]
  4. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nichols, K.E., Crispino, J.D., Poncz, M., White, J.G., Orkin, S.H., Maris, J.M., Weiss, M.J. Nat. Genet. (2000) [Pubmed]
  5. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Iwasaki, H., Mizuno, S., Wells, R.A., Cantor, A.B., Watanabe, S., Akashi, K. Immunity (2003) [Pubmed]
  6. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. Zhou, M., Ouyang, W., Gong, Q., Katz, S.G., White, J.M., Orkin, S.H., Murphy, K.M. J. Exp. Med. (2001) [Pubmed]
  7. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Jacobsen, C.M., Mannisto, S., Porter-Tinge, S., Genova, E., Parviainen, H., Heikinheimo, M., Adameyko, I.I., Tevosian, S.G., Wilson, D.B. Dev. Dyn. (2005) [Pubmed]
  8. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. Hong, W., Nakazawa, M., Chen, Y.Y., Kori, R., Vakoc, C.R., Rakowski, C., Blobel, G.A. EMBO J. (2005) [Pubmed]
  9. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. Wang, X., Crispino, J.D., Letting, D.L., Nakazawa, M., Poncz, M., Blobel, G.A. EMBO J. (2002) [Pubmed]
  10. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Chang, A.N., Cantor, A.B., Fujiwara, Y., Lodish, M.B., Droho, S., Crispino, J.D., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Maeda, K., Nishiyama, C., Tokura, T., Nakano, H., Kanada, S., Nishiyama, M., Okumura, K., Ogawa, H. Blood (2006) [Pubmed]
  12. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Katz, S.G., Cantor, A.B., Orkin, S.H. Mol. Cell. Biol. (2002) [Pubmed]
  13. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Cantor, A.B., Katz, S.G., Orkin, S.H. Mol. Cell. Biol. (2002) [Pubmed]
  14. Friend of GATA (FOG)-1 and FOG-2 differentially repress the GATA-dependent activity of multiple gonadal promoters. Robert, N.M., Tremblay, J.J., Viger, R.S. Endocrinology (2002) [Pubmed]
  15. Molecular markers of cardiac endocardial cushion development. Gitler, A.D., Lu, M.M., Jiang, Y.Q., Epstein, J.A., Gruber, P.J. Dev. Dyn. (2003) [Pubmed]
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