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Gene Review

TRPV3  -  transient receptor potential cation...

Homo sapiens

Synonyms: OLMS, Transient receptor potential cation channel subfamily V member 3, TrpV3, VRL-3, VRL3, ...
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Disease relevance of TRPV3

  • VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1 [1].
  • We also hypothesize that closing of some TRP channels (TRPV3 and/or TRPV4) by lowering temperature may be partly responsible for the neuroprotective effect of hypothermia [2].

High impact information on TRPV3

  • Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses [1].
  • TRPV3 is a temperature-sensitive vanilloid receptor-like protein [1].
  • VRL3 is coded for by a 2,370-base-pair open reading frame, transcribed from a gene adjacent to VR1, and is structurally homologous to VR1 [1].
  • We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels [3].
  • Primary keratinocytes overexpressing exogenous TRPV3 also exhibited biphasic agonist-evoked currents [4].

Biological context of TRPV3

  • An amino-acid substitution at the same position in one gene was detected in DS-Nh mice and WBN/Kob-Ht rats: Gly573 to Ser (Nh mutation) or Gly573 to Cys (Ht mutation), located in the transient receptor potential (TRP) cation channel subfamily V member 3 (TRPV3) gene [5].

Anatomical context of TRPV3

  • In rodents, TRPV3 and TRPV4 proteins have not been detected in sensory neurons but are highly expressed in skin epidermal keratinocytes [6].
  • In addition, low levels of 2APB strongly potentiate the effect of capsaicin, protons, and heat on TRPV1 as well as that of heat on TRPV3 expressed in Xenopus oocytes [7].
  • Short duration (1h) exposure of dissociated sensory neurons to NTFs increased numbers of TRPV1-positive neurons, but not of TRPV3, Nav 1.8 and IK1 and the morphological size-distribution remained similar to intact post-mortem DRG neurons [8].
  • We concluded that TRPV3 was the gene responsible for Nh and Ht mutations, and that mutation in TRPV3 possibly correlated with increased mast cell numbers [5].

Associations of TRPV3 with chemical compounds

  • Similar to menthol, both camphor and cinnamaldehyde (initially reported to be specific activators of TRPV3 and TRPA1, respectively) also modulate other thermoTRPs [9].
  • However, human physiological studies demonstrate a paradoxical role of menthol in modulation of warm sensation, and here, we show that menthol also activates heat-activated TRPV3 [9].

Other interactions of TRPV3


  1. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Smith, G.D., Gunthorpe, M.J., Kelsell, R.E., Hayes, P.D., Reilly, P., Facer, P., Wright, J.E., Jerman, J.C., Walhin, J.P., Ooi, L., Egerton, J., Charles, K.J., Smart, D., Randall, A.D., Anand, P., Davis, J.B. Nature (2002) [Pubmed]
  2. Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Lipski, J., Park, T.I., Li, D., Lee, S.C., Trevarton, A.J., Chung, K.K., Freestone, P.S., Bai, J.Z. Brain Res. (2006) [Pubmed]
  3. Bisandrographolide from Andrographis paniculata Activates TRPV4 Channels. Smith, P.L., Maloney, K.N., Pothen, R.G., Clardy, J., Clapham, D.E. J. Biol. Chem. (2006) [Pubmed]
  4. Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. Chung, M.K., Güler, A.D., Caterina, M.J. J. Biol. Chem. (2005) [Pubmed]
  5. Association of a mutation in TRPV3 with defective hair growth in rodents. Asakawa, M., Yoshioka, T., Matsutani, T., Hikita, I., Suzuki, M., Oshima, I., Tsukahara, K., Arimura, A., Horikawa, T., Hirasawa, T., Sakata, T. J. Invest. Dermatol. (2006) [Pubmed]
  6. Warm temperatures activate TRPV4 in mouse 308 keratinocytes. Chung, M.K., Lee, H., Caterina, M.J. J. Biol. Chem. (2003) [Pubmed]
  7. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. Hu, H.Z., Gu, Q., Wang, C., Colton, C.K., Tang, J., Kinoshita-Kawada, M., Lee, L.Y., Wood, J.D., Zhu, M.X. J. Biol. Chem. (2004) [Pubmed]
  8. The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons. Anand, U., Otto, W.R., Casula, M.A., Day, N.C., Davis, J.B., Bountra, C., Birch, R., Anand, P. Neurosci. Lett. (2006) [Pubmed]
  9. More than cool: promiscuous relationships of menthol and other sensory compounds. Macpherson, L.J., Hwang, S.W., Miyamoto, T., Dubin, A.E., Patapoutian, A., Story, G.M. Mol. Cell. Neurosci. (2006) [Pubmed]
  10. Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes. Kochukov, M.Y., McNearney, T.A., Fu, Y., Westlund, K.N. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
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