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Gene Review

TRPV2  -  transient receptor potential cation...

Homo sapiens

Synonyms: OTRPC2, Osm-9-like TRP channel 2, Transient receptor potential cation channel subfamily V member 2, TrpV2, VRL, ...
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Disease relevance of TRPV2

  • Our data suggest the existence of a common activation mechanism for TRPV1, TRPV2, and TRPV3 that may serve as a therapeutic target for pain management and treatment for diseases caused by hypersensitivity and temperature misregulation [1].
  • It has been demonstrated that TRPV2 is activated by moderate thermal stimuli and, in the rat, is expressed in medium to large diameter dorsal root ganglion neurons [2].
  • These data may also implicate the involvement of TRPV2 in disorders of the hypothalamic-pituitary-adrenal axis, including anxiety, depression, hypertension, and preterm labor [2].
  • The performance of VRL is also evaluated for classifying subjects with normal sinus rhythm and congestive heart failure using the RR intervals taken from the PhysioNet database [3].

Psychiatry related information on TRPV2


High impact information on TRPV2

  • TRPV3 is a temperature-sensitive vanilloid receptor-like protein [5].
  • Here we identify a structurally related receptor, VRL-1, that does not respond to capsaicin, acid or moderate heat [6].
  • Instead, VRL-1 is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells [6].
  • We describe the functional coupling of TRPV2 protein to calcium fluxes and proinflammatory degranulation events in mast cells [7].
  • 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3 [1].

Biological context of TRPV2


Anatomical context of TRPV2

  • A-delta fibres exhibit properties that may be explained by TRPV2 containing channels which is present in large diameter sensory neurons that do not express TRPV1 [11].
  • This is the first study to demonstrate the presence of both TRPV1 and TRPV2 in human peripheral lymphocytes [8].
  • The present study demonstrates both gene and protein expression of TRPV1 and TRPV2 in human peripheral blood cells (PBCs) using molecular and immunocytochemical techniques [8].
  • Immunohistochemical labeling detected TRPV1 and TRPV2 proteins in nodose ganglia [12].
  • We extended the search for TRPV1-TRPV2 co-localization in the brain, where we detected extensive co-expression of the two receptors in the IV, V and VI layer neurons of the adult rat cerebral cortex [9].

Associations of TRPV2 with chemical compounds

  • The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activated TRPV2 [8].
  • These results suggest that fMLP induces translocation of TRPV2 from intracellular compartment to the plasma membrane, and this translocation is critical for fMLP-induced calcium entry [13].
  • Few, if any, cells in these regions expressed TRPV2 immunoreactivity in the absence of oxytocin immunoreactivity or vasopressin immunoreactivity [2].

Other interactions of TRPV2


Analytical, diagnostic and therapeutic context of TRPV2

  • We identified a novel SR-containing protein, named GSRP-56 (Golgi-localized SR-containing protein-56), by a yeast two-hybrid method, using a member of the transient receptor potential channel family, TRPV2, as bait [16].
  • Here, we examined expression patterns of the voltage-gated potassium channel Kv1.4, the nociceptive transduction channels TRPV1 and TRPV2 as well as the putative anti-nociceptive cannabinoid receptor CB1 by immunofluorescence double-labelings in sections of rat dorsal root ganglia (DRGs) [14].
  • When CB1-mRNA was detected using in situ hybridizations an additional subset of larger neurons was labeled including 82.4+/-17.7% of the TRPV2 expressing neurons [14].
  • Isolates examined by pulsed-field gel electrophoresis were indistinguishable from the Latin American epidemic strain, C6707; however, they differed significantly from the endemic Gulf Coast strain (VRL 1984), the sixth-pandemic strain (569-B), and a V. cholerae non-O1 strain isolated from a ship arriving from a foreign port [18].


  1. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. Hu, H.Z., Gu, Q., Wang, C., Colton, C.K., Tang, J., Kinoshita-Kawada, M., Lee, L.Y., Wood, J.D., Zhu, M.X. J. Biol. Chem. (2004) [Pubmed]
  2. Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. Wainwright, A., Rutter, A.R., Seabrook, G.R., Reilly, K., Oliver, K.R. J. Comp. Neurol. (2004) [Pubmed]
  3. An index related to the autocorrelation function of RR intervals for the analysis of heart rate variability. Hwang, J.S., Hu, T.H., Chen, L.C. Physiological measurement. (2006) [Pubmed]
  4. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Delany, N.S., Hurle, M., Facer, P., Alnadaf, T., Plumpton, C., Kinghorn, I., See, C.G., Costigan, M., Anand, P., Woolf, C.J., Crowther, D., Sanseau, P., Tate, S.N. Physiol. Genomics (2001) [Pubmed]
  5. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Smith, G.D., Gunthorpe, M.J., Kelsell, R.E., Hayes, P.D., Reilly, P., Facer, P., Wright, J.E., Jerman, J.C., Walhin, J.P., Ooi, L., Egerton, J., Charles, K.J., Smart, D., Randall, A.D., Anand, P., Davis, J.B. Nature (2002) [Pubmed]
  6. A capsaicin-receptor homologue with a high threshold for noxious heat. Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J., Julius, D. Nature (1999) [Pubmed]
  7. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. Stokes, A.J., Shimoda, L.M., Koblan-Huberson, M., Adra, C.N., Turner, H. J. Exp. Med. (2004) [Pubmed]
  8. Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. Saunders, C.I., Kunde, D.A., Crawford, A., Geraghty, D.P. Mol. Immunol. (2007) [Pubmed]
  9. Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Liapi, A., Wood, J.N. Eur. J. Neurosci. (2005) [Pubmed]
  10. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. Barnhill, J.C., Stokes, A.J., Koblan-Huberson, M., Shimoda, L.M., Muraguchi, A., Adra, C.N., Turner, H. J. Cell. Biochem. (2004) [Pubmed]
  11. TRPV channels as temperature sensors. Benham, C.D., Gunthorpe, M.J., Davis, J.B. Cell Calcium (2003) [Pubmed]
  12. Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Zhang, L., Jones, S., Brody, K., Costa, M., Brookes, S.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  13. Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. Nagasawa, M., Nakagawa, Y., Tanaka, S., Kojima, I. J. Cell. Physiol. (2007) [Pubmed]
  14. Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Binzen, U., Greffrath, W., Hennessy, S., Bausen, M., Saaler-Reinhardt, S., Treede, R.D. Neuroscience (2006) [Pubmed]
  15. Differential distribution of vanilloid receptors in the primary sensory neurons projecting to the dorsal skin and muscles. Tsukagoshi, M., Goris, R.C., Funakoshi, K. Histochem. Cell Biol. (2006) [Pubmed]
  16. Identification and characterization of GSRP-56, a novel Golgi-localized spectrin repeat-containing protein. Kobayashi, Y., Katanosaka, Y., Iwata, Y., Matsuoka, M., Shigekawa, M., Wakabayashi, S. Exp. Cell Res. (2006) [Pubmed]
  17. Identification of kit positive cells in the human urinary tract. van der AA, F., Roskams, T., Blyweert, W., Ost, D., Bogaert, G., De Ridder, D. J. Urol. (2004) [Pubmed]
  18. International dissemination of epidemic Vibrio cholerae by cargo ship ballast and other nonpotable waters. McCarthy, S.A., Khambaty, F.M. Appl. Environ. Microbiol. (1994) [Pubmed]
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