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Gene Review:

IFNLR1 - interferon, lambda receptor 1

Homo sapiens

Synonyms: CRF2-12, CRF2/12, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, IFN-lambda receptor 1, ...

Chae, S.C. et al., Houghton, A.N. et al., Dumoutier, L. et al., Martin, R.F. et al., Liang, K.H., et al.

Kung-Hao Liang,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL28RA

A new cell surface antigen with properties of a glycolipid was defined with an IgM monoclonal antibody secreted by a tetraploid cell derived from a fusion of LICR-2 with lymphocytes from the axillary lymph node of a patient with melanoma [1].

High impact information on IL28RA

Human lymphocytes from lymph node, peripheral blood, spleen, and tumor specimens have been fused with the LICR-LON-HMy2 (LICR-2) or SKO-007 human cell lines or the NS-1 mouse myeloma line [2].
We used IL-28R/LICR2-mutated receptors to identify the tyrosines required for STAT activation, as well as antiproliferative and antiviral activities [3].
In contrast, none of the IL-10-related cytokines described so far could activate LICR2-transfected cells, suggesting that LICR2 is a signalling receptor for a new cytokine of the IL-10 family [4].
This gene, termed likely interleukin or cytokine receptor-2 ( LICR2 ), is located on chromosome 1, at 25 kb from the IL22R (IL-22 receptor) gene, and is constitutively expressed in most tissues [4].
Our results suggested that the g.32349 G>A polymorphism of IL-28RA might be associated with susceptibility to allergic rhinitis (P=0.032), but seems to have no relationship with serum total IgE levels [5].
IL28RA has antisense Alu elements in its 3'UTR region, making it susceptible to the regulation of other protein-coding RNAs with sense Alu elements, and Pol-III transcribed Alus [6].

Biological context of IL28RA

IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene [5].
We scanned the seven exons and their boundary introns sequence of IL-28RA including the promoter regions to analyze genetic variation sites, and identified eighteen single nucleotide polymorphisms (SNPs) and two variation sites [5].

Anatomical context of IL28RA

In the case of peripheral blood lymphocytes, fusion with NS-1 gave greater than 25 times higher frequency of clones than fusion with LICR-2 or SKO-007 [1].
Pokeweed mitogen-stimulated human lymphocytes fused to LICR-2 (HMY2) generate human-human hybridomas producing monoclonal IgG antibodies reactive to human breast carcinoma and malignant melanoma [7].

References

Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma. Houghton, A.N., Brooks, H., Cote, R.J., Taormina, M.C., Oettgen, H.F., Old, L.J. J. Exp. Med. (1983) [Pubmed]
Generation of human monoclonal antibodies reactive with cellular antigens. Cote, R.J., Morrissey, D.M., Houghton, A.N., Beattie, E.J., Oettgen, H.F., Old, L.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. Dumoutier, L., Tounsi, A., Michiels, T., Sommereyns, C., Kotenko, S.V., Renauld, J.C. J. Biol. Chem. (2004) [Pubmed]
Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Dumoutier, L., Lejeune, D., Hor, S., Fickenscher, H., Renauld, J.C. Biochem. J. (2003) [Pubmed]
Analysis of the variations in IL-28RA gene and their association with allergic rhinitis. Chae, S.C., Park, Y.R., Li, C.S., Lee, J.H., Yang, Y.S., Zhang, Q., Kim, K.S., Chung, H.T. Exp. Mol. Med. (2006) [Pubmed]
A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013) [Pubmed]
Pokeweed mitogen-stimulated human lymphocytes fused to LICR-2 (HMY2) generate human-human hybridomas producing monoclonal IgG antibodies reactive to human breast carcinoma and malignant melanoma. Martin, R.F., Kisor, R., Schroer, D., Eichler, G., Filaccio, M.L. Hum. Antibodies Hybridomas (1990) [Pubmed]

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IFNLR1	Bos taurus
IFNLR1	Canis lupus familiaris
LOC711625	Macaca mulatta
Ifnlr1	Mus musculus
IFNLR1	Pan troglodytes
Ifnlr1	Rattus norvegicus

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