Disease relevance of RHOV

• WRCH2 mRNA was up-regulated in 3 out of 8 cases of primary gastric cancer [1].
• WRCH2 mRNA was moderately expressed in MKN74, MKN45, MKN28, KATO-III (gastric cancer), HL-60 (pro-myelocytic leukemia), Raji (Burkitt's lymphoma), and SW480 (colorectal cancer) [1].
• WRCH2 mRNA was over-expressed in TMK1 (gastric cancer), Hs700T (pancreatic cancer), HeLa S3 (cervical cancer), and A549 (lung cancer) [1].

High impact information on RHOV

• However, treatment with inhibitors of protein palmitoylation, but not prenylation, caused Chp to mislocalize to the cytoplasm [2].
• Although Chp lacks aCAAXmotif, we found that Chp showed carboxyl terminus-dependent localization to the plasma membrane and to endosomes [2].
• Results from the microinjection of Chp into cells implicated Chp in the induction of lamellipodia and showed that Chp activates the JNK MAP kinase cascade [3].
• Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton [3].
• WRCH1/ARHV and CDC42 are potentially implicated in the WNT-JNK pathway [1].

Biological context of RHOV

• Molecular cloning and characterization of WRCH2 on human chromosome 15q15 [1].
• A single nucleotide substitution (632 Gright curved arrow A) was identified between WRCH2 cDNA and human genome draft sequences, which resulted in Arg177Lys amino-acid substitution [1].
• WRCH2 gene, consisting of at least 3 exons, encoded a 236-amino-acid protein with proline-rich domain and GTPase domain [1].
• Here, WRCH2/ARHV cDNAs were isolated by using bioinformatics and cDNA-PCR [1].

Anatomical context of RHOV

• WRCH2 mRNA was relatively highly expressed in pancreas, placenta, and fetal brain [1].

References