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Gene Review

RHOU  -  ras homolog family member U

Homo sapiens

Synonyms: ARHU, CDC42-like GTPase 1, CDC42L1, DJ646B12.2, FLJ10616, ...
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Disease relevance of RHOU


High impact information on RHOU

  • Active Wrch-1 stimulates quiescent cells to reenter the cell cycle [2].
  • Taken together, Wrch-1 could mediate the effects of Wnt-1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation [2].
  • Unlike Cdc42, Wrch-1 possesses an extremely rapid, intrinsic guanine nucleotide exchange activity [3].
  • However, Wrch-1 possesses a unique N-terminal 46 amino acid sequence extension that contains putative Src homology 3 (SH3) domain-interacting motifs [3].
  • Silencing of Wrch1 and Arhgef8 expression severely inhibited differentiation and affected osteoclast morphology [4].

Biological context of RHOU


Anatomical context of RHOU

  • Amounts of WRCH1 mRNA in 40 human cancer cell lines were lower than that in normal stomach, pancreas, or placenta [1].
  • WRCH1 mRNA was more highly expressed in corpus callosum, hippocampus, cerebral cortex, and also in several parts within adult brain than in other normal tissues including stomach, pancreas, and placenta [1].
  • WRCH1 mRNA was significantly up-regulated in 4 cases of primary kidney tumors, 1 case each of primary colon, gastric, breast, ovarian, and uterus cancer [1].
  • Approximately half of mutations in random or RV-specific B cells from adults or infants occurred at the DGYW/WRCH or WA/TW hotspot motifs [6].

Associations of RHOU with chemical compounds


Other interactions of RHOU

  • WRCH2 was homologous to WRCH1 (55.4% total-amino-acid identity) and CDC42 (43.5% total-amino-acid identity) [7].


  1. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. Kirikoshi, H., Katoh, M. Int. J. Oncol. (2002) [Pubmed]
  2. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Tao, W., Pennica, D., Xu, L., Kalejta, R.F., Levine, A.J. Genes Dev. (2001) [Pubmed]
  3. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Shutes, A., Berzat, A.C., Cox, A.D., Der, C.J. Curr. Biol. (2004) [Pubmed]
  4. Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. Brazier, H., Stephens, S., Ory, S., Fort, P., Morrison, N., Blangy, A. J. Bone Miner. Res. (2006) [Pubmed]
  5. Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes. Mayorov, V.I., Rogozin, I.B., Adkison, L.R., Frahm, C., Kunkel, T.A., Pavlov, Y.I. BMC Immunol. (2005) [Pubmed]
  6. Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. Weitkamp, J.H., Lafleur, B.J., Greenberg, H.B., Crowe, J.E. Hum. Immunol. (2005) [Pubmed]
  7. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. Katoh, M. Int. J. Oncol. (2002) [Pubmed]
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