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Gene Review

Bmf  -  BCL2 modifying factor

Mus musculus

Synonyms: AW260063, AW411872, Bcl-2-modifying factor
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Disease relevance of Bmf


High impact information on Bmf

  • Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins [2].
  • Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures [2].
  • Signaling from the IL-21 receptor increases the formation of a complex between Bcl-2 and the proapoptotic molecule Bcl-2-modifying factor, resulting in Bepsilon cell apoptosis [3].
  • Bmf (here called Bmf-I) expression in HeLa cells induced apoptosis and reduced colony formation in contrast to Bmf-II and Bmf-III, which had no effect on apoptosis and instead increased colony formation [1].
  • We show that Bmf is regulated by transcriptional activation and alternative splicing and conclude that the relative levels of Bmf isoforms may have a role in regulating growth and survival in B cells and leukemic B-CLL cells [1].

Biological context of Bmf

  • We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis [2].

Anatomical context of Bmf


  1. Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. Morales, A.A., Olsson, A., Celsing, F., Osterborg, A., Jondal, M., Osorio, L.M. Leukemia (2004) [Pubmed]
  2. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Puthalakath, H., Villunger, A., O'Reilly, L.A., Beaumont, J.G., Coultas, L., Cheney, R.E., Huang, D.C., Strasser, A. Science (2001) [Pubmed]
  3. IL-21-induced B{varepsilon} cell apoptosis mediated by natural killer T cells suppresses IgE responses. Harada, M., Magara-Koyanagi, K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., Taniguchi, M. J. Exp. Med. (2006) [Pubmed]
  4. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Villunger, A., Scott, C., Bouillet, P., Strasser, A. Blood (2003) [Pubmed]
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