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Gene Review

BMF  -  Bcl2 modifying factor

Homo sapiens

Synonyms: Bcl-2-modifying factor, FLJ00065
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Disease relevance of BMF


High impact information on BMF

  • Signaling from the IL-21 receptor increases the formation of a complex between Bcl-2 and the proapoptotic molecule Bcl-2-modifying factor, resulting in Bepsilon cell apoptosis [3].
  • Membrane fragments from K562 cells were radioiodinated and allowed to adhere to BMF monolayers [4].
  • Preincubation of fibroblasts with an antibody to VCAM-1 (a ligand of VLA-4) inhibited leukemic cell binding in the majority of cases, which was an effect also observed on cytokine-stimulated BMF [1].
  • Leukemic cells from all cases of AML adhered to BM fibroblast (BMF) monolayers (mean +/- standard error [SE] percentage binding, 30.9% +/- 2.5%; n = 23) and to fibronectin and laminin (mean +/- SE percentage binding, 28.0% +/- 4.1% [n = 11] and 21.5% +/- 2.3% [n = 8], respectively) [5].
  • Treatment of BMF with antifibronectin antibody alone had little effect on ALL adhesion and did not enhance the inhibitory effect of anti-VCAM-1 [1].

Chemical compound and disease context of BMF


Biological context of BMF


Anatomical context of BMF

  • These data suggest that mixed chimaeric pattern of BMF may be correlated with bone marrow hypoplasia [8].
  • Surface antigens in lymphocytes from peripheral blood were assessed in 16 children directly after intensive chemotherapy (i.e., after protocol II of the BMF program) and in 25 children 12-13 months following conclusion of acute lymphoblastic leukemia treatment [9].


  1. Analysis of the mechanism of adhesion of precursor-B acute lymphoblastic leukemia cells to bone marrow fibroblasts. Bradstock, K., Makrynikola, V., Bianchi, A., Byth, K. Blood (1993) [Pubmed]
  2. Bendamustine prolongs progression-free survival in metastatic breast cancer (MBC): a phase III prospective, randomized, multicenter trial of bendamustine hydrochloride, methotrexate and 5-fluorouracil (BMF) versus cyclophosphamide, methotrexate and 5-fluorouracil (CMF) as first-line treatment of MBC. von Minckwitz, G., Chernozemsky, I., Sirakova, L., Chilingirov, P., Souchon, R., Marschner, N., Kleeberg, U., Tsekov, C., Fritze, D., Thomssen, C., Stuart, N., Vermorken, J.B., Loibl, S., Merkle, K.h., Kaufmann, M. Anticancer Drugs (2005) [Pubmed]
  3. IL-21-induced B{varepsilon} cell apoptosis mediated by natural killer T cells suppresses IgE responses. Harada, M., Magara-Koyanagi, K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., Taniguchi, M. J. Exp. Med. (2006) [Pubmed]
  4. Identification of novel K562 membrane proteins that adhere to bone marrow fibroblasts. Bendall, L.J., Bradstock, K.F., Gottlieb, D.J. Blood (1996) [Pubmed]
  5. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms. Bendall, L.J., Kortlepel, K., Gottlieb, D.J. Blood (1993) [Pubmed]
  6. Gall stone dissolving agents. Bouchier, I.A. British medical journal (Clinical research ed.) (1983) [Pubmed]
  7. DNA damage in lymphocytes of rural Indian women exposed to biomass fuel smoke as assessed by the Comet assay. Pandey, A.K., Bajpayee, M., Parmar, D., Rastogi, S.K., Mathur, N., Seth, P.K., Dhawan, A. Environ. Mol. Mutagen. (2005) [Pubmed]
  8. Evaluation of mixed chimaerism and origin of bone marrow derived fibroblastoid cells after allogeneic bone marrow transplantation. Tanaka, J., Kasai, M., Imamura, M., Masauzi, N., Ohizumi, H., Matsuura, A., Morii, K., Kiyama, Y., Naohara, T., Saitoh, M. Br. J. Haematol. (1994) [Pubmed]
  9. Assessment of chosen parameters of the immune system in children with acute lymphoblastic leukemia. Mazur, B., Olejnik, I., Wylezol, I., Sonta-Jakimczyk, D., Szczepanski, T., Karpe, J. Pediatric hematology and oncology. (2003) [Pubmed]
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