The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IL21R  -  interleukin 21 receptor

Homo sapiens

Synonyms: CD360, IL-21 receptor, IL-21R, Interleukin-21 receptor, NILR, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL21R

  • Here we demonstrate that surface IL-21 receptor (R) is expressed at variable levels by chronic lymphocytic leukemia (CLL) B cells freshly isolated from 33 different patients [1].
  • The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody [2].
  • The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia [2].
  • Immunohistochemical staining demonstrated that IL-21R-positive cells were significantly increased in inflamed synovial tissues of RA patients compared with osteoarthritis (OA) and healthy controls [3].
  • We showed that granulomatous inflammation and liver fibrosis were significantly reduced in S. mansoni-infected IL-21R-/- mice and in IL-21R+/+ mice treated with soluble IL-21R-Fc (sIL-21R-Fc) [4].

High impact information on IL21R


Biological context of IL21R


Anatomical context of IL21R

  • IBD LPMC supernatants stimulate MMP secretion by intestinal fibroblasts, and this effect is partly inhibited by IL21R/Fc [10].
  • RESULTS: Constitutive expression of IL-21R was seen in intestinal epithelial cells, but was higher in IBD patients than in controls [6].
  • NK cell IFN-gamma production was dependent on distinct signals mediated by the IL-21R and the FcR and was abrogated in STAT1-deficient NK cells [11].
  • Flow cytometric analysis confirmed that IL-21R was mainly expressed in freshly isolated CD4, CD8, B and NK cells from peripheral blood and synovial fluid, but decreased gradually in T cells 24 h after anti-CD3 stimulation [3].
  • These data indicate that IL-21R is overexpressed in the inflamed synovial membrane and in peripheral blood or synovial fluid leukocytes of RA patients, and that IL-21 enhances local T-cell activation, proliferation and proinflammatory cytokine secretion [3].

Physical interactions of IL21R

  • Although IL-21 binds to the IL-21R expressed on gamma(c)-deficient ED40515(-) cells, IL-21 is unable to transduce any intracytoplasmic signals [12].

Regulatory relationships of IL21R

  • IL-21R expression was up-regulated following cell stimulation via surface CD40 [1].
  • IL-21R was actively transcribed in YM cells, while BCL6 that was under the control of the IL-21R promoter was only moderately expressed at the mRNA and protein level [13].

Other interactions of IL21R


Analytical, diagnostic and therapeutic context of IL21R


  1. Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. de Totero, D., Meazza, R., Zupo, S., Cutrona, G., Matis, S., Colombo, M., Balleari, E., Pierri, I., Fabbi, M., Capaia, M., Azzarone, B., Gobbi, M., Ferrarini, M., Ferrini, S. Blood (2006) [Pubmed]
  2. Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Mitoma, H., Horiuchi, T., Kimoto, Y., Tsukamoto, H., Uchino, A., Tamimoto, Y., Miyagi, Y., Harada, M. Int. J. Mol. Med. (2005) [Pubmed]
  3. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Li, J., Shen, W., Kong, K., Liu, Z. Scand. J. Immunol. (2006) [Pubmed]
  4. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. Pesce, J., Kaviratne, M., Ramalingam, T.R., Thompson, R.W., Urban, J.F., Cheever, A.W., Young, D.A., Collins, M., Grusby, M.J., Wynn, T.A. J. Clin. Invest. (2006) [Pubmed]
  5. IL-21-induced B{varepsilon} cell apoptosis mediated by natural killer T cells suppresses IgE responses. Harada, M., Magara-Koyanagi, K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., Taniguchi, M. J. Exp. Med. (2006) [Pubmed]
  6. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Caruso, R., Fina, D., Peluso, I., Stolfi, C., Fantini, M.C., Gioia, V., Caprioli, F., Del Vecchio Blanco, G., Paoluzi, O.A., Macdonald, T.T., Pallone, F., Monteleone, G. Gastroenterology (2007) [Pubmed]
  7. Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Wu, Z., Kim, H.P., Xue, H.H., Liu, H., Zhao, K., Leonard, W.J. Mol. Cell. Biol. (2005) [Pubmed]
  8. Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells. Ueda, M., Imada, K., Imura, A., Koga, H., Hishizawa, M., Uchiyama, T. Br. J. Haematol. (2005) [Pubmed]
  9. Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. Hecker, M., Bohnert, A., König, I.R., Bein, G., Hackstein, H. Genes Immun. (2003) [Pubmed]
  10. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Monteleone, G., Caruso, R., Fina, D., Peluso, I., Gioia, V., Stolfi, C., Fantini, M.C., Caprioli, F., Tersigni, R., Alessandroni, L., Macdonald, T.T., Pallone, F. Gut (2006) [Pubmed]
  11. Interleukin-21 enhances NK cell activation in response to antibody-coated targets. Roda, J.M., Parihar, R., Lehman, A., Mani, A., Tridandapani, S., Carson, W.E. J. Immunol. (2006) [Pubmed]
  12. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. J. Immunol. (2001) [Pubmed]
  13. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Ueda, C., Akasaka, T., Kurata, M., Maesako, Y., Nishikori, M., Ichinohasama, R., Imada, K., Uchiyama, T., Ohno, H. Oncogene (2002) [Pubmed]
  14. IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes. Peluso, I., Fantini, M.C., Fina, D., Caruso, R., Boirivant, M., Macdonald, T.T., Pallone, F., Monteleone, G. J. Immunol. (2007) [Pubmed]
  15. Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Zhang, J.L., Foster, D., Sebald, W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
WikiGenes - Universities