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Gene Review

erm-1  -  Protein ERM-1

Caenorhabditis elegans

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High impact information on erm-1

  • We used RNA interference (RNAi) approach to assay ERM proteins of the Caenorhabditis elegans genome for a possible involvement in apical junction (AJ) assembly or positioning [1].
  • Members of the ezrin-radixin-moesin (ERM) family of proteins have been found to serve as linkers between membrane proteins and the F-actin cytoskeleton in many organisms [1].
  • We also show that act-5/cytoplasmic actin and sma-1/beta-H-spectrin are required for lumen formation and functionally interact with erm-1 [2].
  • Confocal and ultrastructural analyses indicate that erm-1 functions directly in apical membrane morphogenesis, rather than in epithelial polarity and junction assembly as has been previously proposed for ERMs [2].
  • RNA interference (RNAi), a germline deletion, and overexpression of erm-1 cause cystic luminal phenotypes in these epithelia [2].


  1. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden, D., Johnson, K., Segbert, C., Bossinger, O. Dev. Biol. (2004) [Pubmed]
  2. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Göbel, V., Barrett, P.L., Hall, D.H., Fleming, J.T. Dev. Cell (2004) [Pubmed]
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