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Gene Review

Msn  -  moesin

Mus musculus

Synonyms: C78546, Membrane-organizing extension spike protein, Moesin
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Disease relevance of Msn


High impact information on Msn


Biological context of Msn

  • The murine Msn locus was mapped to the X chromosome as well by studying a rodent x mouse hybrid panel [7].
  • CONCLUSION: These changes in proximal Na/Pi cotransport may involve a signal transduction cascade including PDZ-dc1, ezrin, moesin, our phosphoprotein, and possibly other proteins [8].
  • Experiments with full-length and truncated bacterial fusion proteins localized the actin-binding site in moesin to the extreme carboxy terminus, a highly conserved sequence [9].
  • Furthermore, morpholino antisense and shRNA approaches show that moesin expression is essential since its knockdown leads to altered F-actin distribution and subsequent apoptosis [1].
  • Our study demonstrates a link between Galpha13 signaling that regulates differentiation of F9 cells through primitive to parietal endoderm and a moesin requirement for cell survival [1].

Anatomical context of Msn


Associations of Msn with chemical compounds


Other interactions of Msn


Analytical, diagnostic and therapeutic context of Msn


  1. Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. Krawetz, R., Mackenzie, M.J., Sun, Q., Walton, P.A., Kelly, G.M. Exp. Cell Res. (2006) [Pubmed]
  2. Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Eto, M., Bock, R., Brautigan, D.L., Linden, D.J. Neuron (2002) [Pubmed]
  3. Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. Tamura, A., Kikuchi, S., Hata, M., Katsuno, T., Matsui, T., Hayashi, H., Suzuki, Y., Noda, T., Tsukita, S., Tsukita, S. J. Cell Biol. (2005) [Pubmed]
  4. Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. Defacque, H., Egeberg, M., Habermann, A., Diakonova, M., Roy, C., Mangeat, P., Voelter, W., Marriott, G., Pfannstiel, J., Faulstich, H., Griffiths, G. EMBO J. (2000) [Pubmed]
  5. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., Tsukita, S. J. Cell Biol. (1994) [Pubmed]
  6. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. Sala-Valdés, M., Ursa, A., Charrin, S., Rubinstein, E., Hemler, M.E., Sánchez-Madrid, F., Yáñez-Mó, M. J. Biol. Chem. (2006) [Pubmed]
  7. Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN). Wilgenbus, K.K., Hsieh, C.L., Lankes, W.T., Milatovich, A., Francke, U., Furthmayr, H. Genomics (1994) [Pubmed]
  8. Molecular effects of volume expansion on the renal sodium phosphate cotransporter. Puschett, J.B., Whitbred, J., Ianosi-Irimie, M., Vu, H.V., Rabon, E., Robinson, J., Deininger, P. Am. J. Med. Sci. (2003) [Pubmed]
  9. Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes. Pestonjamasp, K., Amieva, M.R., Strassel, C.P., Nauseef, W.M., Furthmayr, H., Luna, E.J. Mol. Biol. Cell (1995) [Pubmed]
  10. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. Sato, N., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., Tsukita, S. J. Cell. Sci. (1992) [Pubmed]
  11. Foxj1 is required for apical localization of ezrin in airway epithelial cells. Huang, T., You, Y., Spoor, M.S., Richer, E.J., Kudva, V.V., Paige, R.C., Seiler, M.P., Liebler, J.M., Zabner, J., Plopper, C.G., Brody, S.L. J. Cell. Sci. (2003) [Pubmed]
  12. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. Doi, Y., Itoh, M., Yonemura, S., Ishihara, S., Takano, H., Noda, T., Tsukita, S. J. Biol. Chem. (1999) [Pubmed]
  13. Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation. Matsumoto, H., Daikoku, T., Wang, H., Sato, E., Dey, S.K. Biol. Reprod. (2004) [Pubmed]
  14. Involvement of gicerin in the extension of microvilli. Okumura, S., Muraoka, O., Tsukamoto, Y., Tanaka, H., Kohama, K., Miki, N., Taira, E. Exp. Cell Res. (2001) [Pubmed]
  15. Biochemical, electron microscopic and immunohistological observations of cationic detergent-extracted cells: detection and improved preservation of microextensions and ultramicroextensions. Nakamura, F. BMC Cell Biol. (2001) [Pubmed]
  16. Imaging of dynamic changes of the actin cytoskeleton in microextensions of live NIH3T3 cells with a GFP fusion of the F-actin binding domain of moesin. Litman, P., Amieva, M.R., Furthmayr, H. BMC Cell Biol. (2000) [Pubmed]
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