Gene Review:
Mdm4 - transformed mouse 3T3 cell double minute 4
Mus musculus
Synonyms:
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, ...
- Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Xiong, S., Van Pelt, C.S., Elizondo-Fraire, A.C., Liu, G., Lozano, G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Danovi, D., Meulmeester, E., Pasini, D., Migliorini, D., Capra, M., Frenk, R., de Graaf, P., Francoz, S., Gasparini, P., Gobbi, A., Helin, K., Pelicci, P.G., Jochemsen, A.G., Marine, J.C. Mol. Cell. Biol. (2004)
- Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Parant, J., Chavez-Reyes, A., Little, N.A., Yan, W., Reinke, V., Jochemsen, A.G., Lozano, G. Nat. Genet. (2001)
- Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Grier, J.D., Xiong, S., Elizondo-Fraire, A.C., Parant, J.M., Lozano, G. Mol. Cell. Biol. (2006)
- Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Migliorini, D., Lazzerini Denchi, E., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P.G., Marine, J.C. Mol. Cell. Biol. (2002)
- Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth. Steinman, H.A., Sluss, H.K., Sands, A.T., Pihan, G., Jones, S.N. Oncogene (2004)
- Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Steinman, H.A., Hoover, K.M., Keeler, M.L., Sands, A.T., Jones, S.N. Oncogene (2005)
- A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Toledo, F., Krummel, K.A., Lee, C.J., Liu, C.W., Rodewald, L.W., Tang, M., Wahl, G.M. Cancer Cell (2006)
- Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Iwakuma, T., Parant, J.M., Fasulo, M., Zwart, E., Jacks, T., de Vries, A., Lozano, G. Oncogene (2004)
- MDMX: a novel p53-binding protein with some functional properties of MDM2. Shvarts, A., Steegenga, W.T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R.C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A.J., Jochemsen, A.G. EMBO J. (1996)