Gene Review:
MDM4 - MDM4, p53 regulator
Homo sapiens
Synonyms:
Double minute 4 protein, HDMX, MDMX, MRP1, Mdm2-like p53-binding protein, ...
- Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Riemenschneider, M.J., Büschges, R., Wolter, M., Reifenberger, J., Boström, J., Kraus, J.A., Schlegel, U., Reifenberger, G. Cancer Res. (1999)
- Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Bartel, F., Schulz, J., Böhnke, A., Blümke, K., Kappler, M., Bache, M., Schmidt, H., Würl, P., Taubert, H., Hauptmann, S. Int. J. Cancer (2005)
- Real-time quantitative PCR analysis of regions involved in gene amplification reveals gene overdose in low-grade astrocytic gliomas. Arjona, D., Bello, M.J., Alonso, M.E., Isla, A., De Campos, J.M., Vaquero, J., Sarasa, J.L., Gutierrez, M., Rey, J.A. Diagn. Mol. Pathol. (2005)
- MDMX: from bench to bedside. Marine, J.C., Dyer, M.A., Jochemsen, A.G. J. Cell. Sci. (2007)
- An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells. Smalley, K.S., Contractor, R., Haass, N.K., Kulp, A.N., Atilla-Gokcumen, G.E., Williams, D.S., Bregman, H., Flaherty, K.T., Soengas, M.S., Meggers, E., Herlyn, M. Cancer Res. (2007)
- Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Parant, J., Chavez-Reyes, A., Little, N.A., Yan, W., Reinke, V., Jochemsen, A.G., Lozano, G. Nat. Genet. (2001)
- 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. Jin, Y., Dai, M.S., Lu, S.Z., Xu, Y., Luo, Z., Zhao, Y., Lu, H. EMBO J. (2006)
- Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. LeBron, C., Chen, L., Gilkes, D.M., Chen, J. EMBO J. (2006)
- MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis. Mancini, F., Gentiletti, F., D'Angelo, M., Giglio, S., Nanni, S., D'Angelo, C., Farsetti, A., Citro, G., Sacchi, A., Pontecorvi, A., Moretti, F. J. Biol. Chem. (2004)
- Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. Shvarts, A., Bazuine, M., Dekker, P., Ramos, Y.F., Steegenga, W.T., Merckx, G., van Ham, R.C., van der Houven van Oordt, W., van der Eb, A.J., Jochemsen, A.G. Genomics (1997)
- ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. Chen, L., Gilkes, D.M., Pan, Y., Lane, W.S., Chen, J. EMBO J. (2005)
- MDMX: a novel p53-binding protein with some functional properties of MDM2. Shvarts, A., Steegenga, W.T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R.C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A.J., Jochemsen, A.G. EMBO J. (1996)
- MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Gentiletti, F., Mancini, F., D'Angelo, M., Sacchi, A., Pontecorvi, A., Jochemsen, A.G., Moretti, F. Oncogene (2002)
- Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Boesten, L.S., Zadelaar, S.M., De Clercq, S., Francoz, S., van Nieuwkoop, A., Biessen, E.A., Hofmann, F., Feil, S., Feil, R., Jochemsen, A.G., Zurcher, C., Havekes, L.M., van Vlijmen, B.J., Marine, J.C. Cell Death Differ. (2006)
- A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection. Wang, Z., Wang, B., Tang, K., Lee, E.J., Chong, S.S., Lee, C.G. Hum. Mol. Genet. (2005)
- MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Huang, C.L., Ueno, M., Liu, D., Masuya, D., Nakano, J., Yokomise, H., Nakagawa, T., Miyake, M. Oncogene (2006)
- Modification of MDMX by sumoylation. Pan, Y., Chen, J. Biochem. Biophys. Res. Commun. (2005)
- MDMX regulation of p53 response to ribosomal stress. Gilkes, D.M., Chen, L., Chen, J. EMBO J. (2006)
- A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation. Strachan, G.D., Rallapalli, R., Pucci, B., Lafond, T.P., Hall, D.J. J. Biol. Chem. (2001)
- MDM2 and MDMX bind and stabilize the p53-related protein p73. Ongkeko, W.M., Wang, X.Q., Siu, W.Y., Lau, A.W., Yamashita, K., Harris, A.L., Cox, L.S., Poon, R.Y. Curr. Biol. (1999)
- Regulation of p53-MDMX interaction by casein kinase 1 alpha. Chen, L., Li, C., Pan, Y., Chen, J. Mol. Cell. Biol. (2005)
- The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. Strachan, G.D., Jordan-Sciutto, K.L., Rallapalli, R., Tuan, R.S., Hall, D.J. J. Cell. Biochem. (2003)
- MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Yam, C.H., Siu, W.Y., Arooz, T., Chiu, C.H., Lau, A., Wang, X.Q., Poon, R.Y. Cancer Res. (1999)
- Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells. Rallapalli, R., Strachan, G., Tuan, R.S., Hall, D.J. J. Cell. Biochem. (2003)
- Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. Lopez-Pajares, V., Kim, M.M., Yuan, Z.M. J. Biol. Chem. (2008)
- Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. Riemenschneider, M.J., Knobbe, C.B., Reifenberger, G. Int. J. Cancer (2003)
- Loss of Kv and MaxiK currents associated with increased MRP1 expression in small cell lung carcinoma. Lam, H.D., Lemay, A.M., Kelly, J., Hill, C.E. J. Cell. Physiol. (2006)