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Gene Review

cki-1  -  Protein CKI-1

Caenorhabditis elegans

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High impact information on cki-1


Biological context of cki-1


Anatomical context of cki-1


Associations of cki-1 with chemical compounds


Other interactions of cki-1

  • C. elegans cki-1 encodes a member of the CIP/KIP family of cyclin-dependent kinase inhibitors, and functions to link postembryonic developmental programs to cell cycle progression [7].


  1. The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans. Saito, R.M., Perreault, A., Peach, B., Satterlee, J.S., van den Heuvel, S. Nat. Cell Biol. (2004) [Pubmed]
  2. mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage. Nimmo, R., Antebi, A., Woollard, A. Development (2005) [Pubmed]
  3. Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Kostić, I., Roy, R. Development (2002) [Pubmed]
  4. lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Boxem, M., van den Heuvel, S. Development (2001) [Pubmed]
  5. Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans. Fukuyama, M., Gendreau, S.B., Derry, W.B., Rothman, J.H. Dev. Biol. (2003) [Pubmed]
  6. cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad. Kostić, I., Li, S., Roy, R. Dev. Biol. (2003) [Pubmed]
  7. Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Hong, Y., Roy, R., Ambros, V. Development (1998) [Pubmed]
  8. DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Baugh, L.R., Sternberg, P.W. Curr. Biol. (2006) [Pubmed]
  9. Caenorhabditis elegans Elongin BC complex is essential for cell proliferation and chromosome condensation and segregation during mitosis and meiotic division II. Sasagawa, Y., Kikuchi, K., Dazai, K., Higashitani, A. Chromosome Res. (2005) [Pubmed]
  10. Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. Furukawa, T., Ogura, T., Zheng, Y.J., Tsuchiya, H., Nakaya, H., Katayama, Y., Inagaki, N. J. Physiol. (Lond.) (2002) [Pubmed]
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