Disease relevance of Microsurgery

• To examine the long term effectiveness of transsphenoidal microsurgery for patients with PRL-secreting pituitary tumors, we studied 54 women at yearly intervals after transsphenoidal surgery [1].
• Several approaches are available for treating pituitary ACTH-dependent Cushing's syndrome, but transsphenoidal pituitary microsurgery is the ideal type, with remission of the disease being observed in 80 to 90% of cases [2].
• Primary microsurgery for postinflammatory tubal infertility [3].
• Simultaneous intrauterine twins and tubal pregnancy after conservative microsurgery for ectopic pregnancy in a patient with a single tube: case report [4].
• Transanal endoscopic microsurgery in large, sessile adenomas of the rectum. A 10-year experience [5].

High impact information on Microsurgery

• Prolactin-secreting tumours of the pituitary were identified and treated by transsphenoidal microsurgery in fourteen infertile females with hyperprolactinaemia [6].
• We find that when centrosomes are completely destroyed by laser microsurgery in CHO cells arrested in S phase by hydroxyurea, new centrosomes form by de novo assembly [7].
• Laser microsurgery and behavioral experiments reveal that sensory input from different subsets of octanol-sensing neurons is selectively used, depending on stimulus strength, feeding status, and 5-HT levels [8].
• In VHL, microsurgery or radiosurgery cannot prevent new HBs from arising in the CNS or coagulation of retinal HBs [9].
• The majority of patients with Cushing's disease can be cured by transsphenoidal microsurgery; however, precise localization of the pituitary source of ACTH is not always possible by standard imaging techniques [10].

Chemical compound and disease context of Microsurgery

• Toxicity may develop clinically if a high concentration of lidocaine is applied on a vessel during microsurgery [11].
• Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery [12].
• It is concluded that administration of dopamine agonists for some weeks prior to surgery is a useful adjunct to transsphenoidal microsurgery for macroprolactinomas [13].
• At the start of transsphenoidal microsurgery for removal of various types of pituitary adenomas, 21 patients received a 1-hour intravenous infusion of 5-bromodeoxyuridine (BUdR, 200 mg/sq m) to label tumor cells in the deoxyribonucleic acid (DNA) synthesis phase (S-phase) [14].
• Assessment of definitive residual pituitary-adrenal function and of hydrocortisone replacement therapy 10 to 14 days after microsurgery for pituitary adenomas [15].

Biological context of Microsurgery

• First and subsequent pregnancies after tubal microsurgery: evaluation of the fertility index [16].
• A method combining recovery of a preovulatory oocyte, its in vitro insemination, and transfer into the oviduct with tubal microsurgery at a single laparotomy is described [17].
• It is concluded that patients who in addition to tubal microsurgery have been treated with AID for 9-12 menstrual cycles seem to have about a 50% poorer chance of achieving a term pregnancy compared with patients whose husbands have normal semen quality [18].
• When, during microsurgery, glycine is used in place of lactated Ringer's solution, the origin of the bleeding site can be easily isolated and coagulated during irrigation, assisting the surgeon in precise and complete hemostasis [19].
• Carbon dioxide microsurgery in gynecology [20].

Anatomical context of Microsurgery

• A comparison of glyceryl trinitrate and labetalol as hypotensive agents in microsurgery of the middle ear [21].
• In embryos deprived of secondary mesenchyme cell (SMC) by microsurgery, the number of SRC decreased considerably [22].
• Thus, the CO2 laser can significantly reduce postoperative adhesions in microsurgical uterine tube reanastomosis but without any significant histologic difference in tissue reunion, compared with conventional microsurgery [23].
• Plasma membranes of such cells have been freshly prepared by freehand microsurgery and are tightly fixed over a 30-micrometers phi hole between two compartments of a microchamber containing 2.0 mM GABA in 7.5 microliters and 0.2 mM GABA in 75 microliters, respectively [24].
• SETTING: Cell Biology Laboratory and the Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel. METHODS: In an in vitro study, cultured bovine corneal endothelial cells were exposed to diluted PI [25].

Associations of Microsurgery with chemical compounds

• Ninety-five patients undergoing microsurgery of the middle ear were anaesthetised using thiopentone, nitrous oxide, oxygen and halothane via a low flow circle system, with carbon-dioxide absorption [21].
• Additional studies will be required to determine if normalization of the circadian cortisol rhythm occurs in all patients with Cushing's disease who are cured after transsphenoidal microsurgery and who also show normal ACTH reserve [26].
• We previously reported that vascularized bone allograft using immunosuppressants, such as cyclosporine A (CsA), is one approach for reconstruction of large bone defects in both experimental animals (Microsurgery 15:663; 1994) and clinically in humans (Lancet 347:970, 1996) [27].
• METHODS: The concentration of putrescine, spermidine, and spermine, and the activity of ODC were biochemically quantified in tissue samples obtained during open microsurgery of 670 patients with brain tumours [28].
• CO2 laser microsurgery differs from previous methods in that extremely fine and controlled therapy can be conducted with minimal damage to surrounding tissues and organs [29].

Gene context of Microsurgery

• Our results suggest potential benefits via inhibition of iNOS to improve clinical outcomes not only for hand surgeons who work in the microsurgery field, but also for other physicians whose work involves ischemia/reperfusion injury [30].
• In one out of two patients who had previously undergone unsuccessful pituitary microsurgery, neither basal nor oCRH-induced ACTH increases led to correct localization of the microadenoma within the pituitary [31].
• CRH test after pituitary microsurgery suggests tertiary adrenocortical insufficiency in successful operated patients with Cushing's disease [32].
• All 20 had bilateral proximal tubal obstruction without other tubal disease, and all had been recommended for tubal microsurgery or in vitro fertilization [33].
• To characterize trophoblast cell-specific secretions, the inner cell mass was removed from all embryos by microsurgery on Day 13 [34].

Analytical, diagnostic and therapeutic context of Microsurgery

• RESULTS--In 65 women microsurgery followed tubal reocclusion after failed conventionally performed salpingostomy [35].
• Difficult choices between surgical (microsurgery/laparoscopy) treatments and in-vitro fertilization (IVF) still confront many workers [36].
• Adhesions were most pronounced after diathermy and least pronounced after microsurgery or indomethacin therapy [37].
• This experience suggests that the CO2 laser now represents a safe and effective alternative to electrosurgery in tubal microsurgery [38].
• Laparoscopic microsurgery offers an alternative to assisted reproductive technology in patients with post-ectopic tubal obstruction in a single Fallopian tube [39].

References