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Gene Review

pie-1  -  Protein PIE-1

Caenorhabditis elegans

 
 
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High impact information on pie-1

  • In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres adopt an MS-like fate [1].
  • The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos [1].
  • The localization and genetic properties of pie-1 provide an example of a repressor-based mechanism for preserving pluripotency within a stem cell lineage [2].
  • The CCCH zinc finger protein PIE-1 is an essential regulator of germ cell fate that segregates with the germ lineage during the first cleavages of the Caenorhabditis elegans embryo [3].
  • An alteration of this sequence element that blocks repression also impairs the ability of a transgene to rescue a pie-1 mutation, suggesting that this repressor activity may be important for PIE-1 function in vivo [4].
 

Biological context of pie-1

  • Lastly, cell manipulations in pie-1 mutant embryos, in which the P2 cell is transformed to an EMS-like fate and produces a gut cell lineage, revealed that gut fate is segregated to one of P2's daughters cell-autonomously [5].
 

Anatomical context of pie-1

 

Other interactions of pie-1

  • Two genes, skn-1 and pie-1, are required for specifying the different identities of two sister blastomeres in a 4-cell embryo, called P2 and EMS [6].
  • Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo [7].
  • However, mutations in pos-1 cause several defects in the development of the germline blastomeres that are distinct from those caused by mutations in pie-1 or mex-1 [8].
  • In mbk-2 mutants, the initial mitotic spindle is misplaced and cytoplasmic factors, including the germline-specific protein PIE-1, are mislocalized [9].

References

  1. The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos. Mello, C.C., Draper, B.W., Krause, M., Weintraub, H., Priess, J.R. Cell (1992) [Pubmed]
  2. The PIE-1 protein and germline specification in C. elegans embryos. Mello, C.C., Schubert, C., Draper, B., Zhang, W., Lobel, R., Priess, J.R. Nature (1996) [Pubmed]
  3. PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans. Tenenhaus, C., Subramaniam, K., Dunn, M.A., Seydoux, G. Genes Dev. (2001) [Pubmed]
  4. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Batchelder, C., Dunn, M.A., Choy, B., Suh, Y., Cassie, C., Shim, E.Y., Shin, T.H., Mello, C., Seydoux, G., Blackwell, T.K. Genes Dev. (1999) [Pubmed]
  5. An analysis of the response to gut induction in the C. elegans embryo. Goldstein, B. Development (1995) [Pubmed]
  6. Determinants of blastomere identity in the early C. elegans embryo. Bowerman, B. Bioessays (1995) [Pubmed]
  7. Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo. Mango, S.E., Thorpe, C.J., Martin, P.R., Chamberlain, S.H., Bowerman, B. Development (1994) [Pubmed]
  8. pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans. Tabara, H., Hill, R.J., Mello, C.C., Priess, J.R., Kohara, Y. Development (1999) [Pubmed]
  9. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Pang, K.M., Ishidate, T., Nakamura, K., Shirayama, M., Trzepacz, C., Schubert, C.M., Priess, J.R., Mello, C.C. Dev. Biol. (2004) [Pubmed]
 
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