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Gene Review:

Sik1 - salt inducible kinase 1

Mus musculus

Synonyms: HRT-20, Msk, Myocardial SNF1-like kinase, SIK-1, Salt-inducible kinase 1, ...

Katoh, Y. et al., Takemori, H. et al., Lin , X. et al., Feldman, J.D. et al., Katoh, Y. et al., et al.

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High impact information on Snf1lk

Salt-inducible kinase (SIK), first cloned from the adrenal glands of rats fed a high salt diet, is a serine/threonine protein kinase belonging to an AMP-activated protein kinase family [1].
ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells [2].
SIK translocation was blocked by pretreatment with leptomycin B [2].
A mutant SIK whose Ser-577, the cAMP-dependent protein kinase (PKA)-dependent phosphorylation site, was replaced with Ala could not move out of the nucleus under stimulation by ACTH [2].
Addition of forskolin to the culture medium enhanced the cholesterol side-chain cleavage cytochrome P450 promoter activity, but the forskolin-dependently activated promoter activity was inhibited when the cells were transfected with a salt-inducible kinase expression vector [3].

Biological context of Snf1lk

Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis [4].
Taken together, these results suggest that the SIK isoforms regulate hormonal signal transduction in both adrenal and adipose tissues [4].
We conclude that the nucleocytoplasmic shuttling of SIK may play an important role in the transcriptional regulation of the cAMP-responsive element (CRE)-dependent gene expression [5].
The disruption of the serine residue inhibited the nuclear export and enhanced the transcription repression activity of SIK [5].

Anatomical context of Snf1lk

One of these genes, SIK (salt-inducible kinase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets [6].
Immunocytochemical and GFP-fluorocytochemical analyses indicated that SIK was present both in the nucleus and cytosol of resting cells [5].

Other interactions of Snf1lk

Responding to ACTH, the nuclear SIK moved to the cytosol [5].

References

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. Horike, N., Takemori, H., Katoh, Y., Doi, J., Min, L., Asano, T., Sun, X.J., Yamamoto, H., Kasayama, S., Muraoka, M., Nonaka, Y., Okamoto, M. J. Biol. Chem. (2003) [Pubmed]
ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells. Takemori, H., Katoh, Y., Horike, N., Doi, J., Okamoto, M. J. Biol. Chem. (2002) [Pubmed]
Salt-inducible kinase is involved in the ACTH/cAMP-dependent protein kinase signaling in Y1 mouse adrenocortical tumor cells. Lin , X., Takemori, H., Katoh, Y., Doi, J., Horike, N., Makino, A., Nonaka, Y., Okamoto, M. Mol. Endocrinol. (2001) [Pubmed]
Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. Katoh, Y., Takemori, H., Horike, N., Doi, J., Muraoka, M., Min, L., Okamoto, M. Mol. Cell. Endocrinol. (2004) [Pubmed]
Identification of the nuclear localization domain of salt-inducible kinase. Katoh, Y., Takemori, H., Doi, J., Okamoto, M. Endocr. Res. (2002) [Pubmed]
The salt-inducible kinase, SIK, is induced by depolarization in brain. Feldman, J.D., Vician, L., Crispino, M., Hoe, W., Baudry, M., Herschman, H.R. J. Neurochem. (2000) [Pubmed]

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