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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

let-70  -  Protein LET-70

Caenorhabditis elegans

 
 
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High impact information on let-70

 

Analytical, diagnostic and therapeutic context of let-70

  • Transgenic analysis using ubc-2-lacZ fusions and in situ immunofluorescence indicate that ubc-2 is abundantly expressed in most tissues of embryos and early larvae, but becomes specific to the nervous system in L4 larvae and adults [1].
  • Western blots (immunoblots) of ubc4 ubc5 yeast cells transformed with ubc-2 reveal a protein of the expected size, which cross-reacts with anti-Drosophila UbcD1 antibody [2].
  • Purification, crystallization and preliminary X-ray analysis of Caenorhabditis elegans ubiquitin-conjugation enzyme M7.1 [3].

References

  1. An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in th nematode Caenorhabditis elegans. Zhen, M., Schein, J.E., Baillie, D.L., Candido, E.P. EMBO J. (1996) [Pubmed]
  2. The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation. Zhen, M., Heinlein, R., Jones, D., Jentsch, S., Candido, E.P. Mol. Cell. Biol. (1993) [Pubmed]
  3. Purification, crystallization and preliminary X-ray analysis of Caenorhabditis elegans ubiquitin-conjugation enzyme M7.1. Gavira J, J.A., Claxton, D.P., Wang, J.H., Toh, D., Meehan, E.J., DiGiammarino, E.L. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
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