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Gene Review:

Mup5 - major urinary protein 5

Mus musculus

Synonyms: MUP 5, Major urinary protein 5, Mup V

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Disease relevance of Mup5

mAbs produced by immunization of BALB/c mice with Streptococcus pyogenes M type 5 membranes were further characterized for their reaction with S. pyogenes pep M5 protein and with autoantigens associated with human cell lines. mAbs 36.2.2 and 54.2.8 simultaneously reacted with M protein and a membrane protein(s) of S. pyogenes [1].

High impact information on Mup5

Immunization of BALB/c mice with each of the overlapping M5 peptides revealed myosin-cross-reactive B-cell epitopes throughout the A and C repeat regions and one major epitope in the B repeat region containing the previously reported Gln-Lys-Ser-Lys-Gln (QKSKQ) epitope [2].
Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein [2].
In mouse the atropine-resistant and therefore the nonadrenergic, noncholinergic component of contractile response to EFS was reduced by M-5, M-14 and propiverine, but was hardly affected by M-6 [3].
Propiverine, M-5 and M-14 reduced the maximum CCh effect, suggesting at least one additional mode of action [3].
By polymerase chain reaction, we identified two cDNA segments encoding MUP 4 and MUP 5 genes in the nose [4].

Biological context of Mup5

Hydroxylation of Am-80 to yield 7-hydroxy-Am-80 (M-4) and 6-hydroxy-Am-80 (M-3), which lead to the formation of 6-oxo-Am-80 (M-5), were commonly observed in all animal species [5].

Anatomical context of Mup5

Cholinergic agents elicit prominent smooth muscle contractions via stimulation of muscarinic receptors that comprise five distinct subtypes (M1-M5) [6].

Associations of Mup5 with chemical compounds

We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human, pig and mouse urinary bladder preparations in order to elucidate the nature of a possible additional mode of action [3].

References

Polyspecificity of antistreptococcal murine monoclonal antibodies and their implications in autoimmunity. Cunningham, M.W., Swerlick, R.A. J. Exp. Med. (1986) [Pubmed]
Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein. Cunningham, M.W., Antone, S.M., Smart, M., Liu, R., Kosanke, S. Infect. Immun. (1997) [Pubmed]
Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction. Wuest, M., Hecht, J., Christ, T., Braeter, M., Schoeberl, C., Hakenberg, O.W., Wirth, M.P., Ravens, U. Br. J. Pharmacol. (2005) [Pubmed]
Expression of major urinary protein genes in the nasal glands associated with general olfaction. Utsumi, M., Ohno, K., Kawasaki, Y., Tamura, M., Kubo, T., Tohyama, M. J. Neurobiol. (1999) [Pubmed]
Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl] benzoic acid. 4th communication: absorption, metabolism, excretion and plasma protein binding in various animals and man. Mizojiri, K., Okabe, H., Sugeno, K., Misaki, A., Ito, M., Kominami, G., Esumi, Y., Takaichi, M., Harada, T., Seki, H., Inaba, A. Arzneimittel-Forschung. (1997) [Pubmed]
Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. Matsui, M., Motomura, D., Fujikawa, T., Jiang, J., Takahashi, S., Manabe, T., Taketo, M.M. J. Neurosci. (2002) [Pubmed]

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