Disease relevance of Galloxon

• Laryngeal paralysis in Arabian foals associated with oral haloxon administration [1].
• Haloxon and carpetweed have each been reported to cause posterior paresis in livestock [2].
• Haloxon was administered orally at 20, 25, and 35 mg/kg of body weight [3].

High impact information on Galloxon

• Structure-inhibition relationships in the interaction of butyrylcholinesterase with bambuterol, haloxon and their leaving groups [4].
• Controlled trials were conducted to evaluate the anthelmintic action of haloxon in 2 phenotypes of lambs, 1 having an A esterase in plasma which rapidly hydrolyzes di-(2-chloroethyl)aryl phosphates and the other without this enzyme [3].
• Nematodes against which haloxon was evaluated in the abomasum were Ostertagia circumcincta and Trichostrongylus axei and in the small intestine were T vitrinus, T colubriformis, Nematodirus spathiger, and N filicollis [3].
• N-Ethylmaleimide, p-chloromercuribenzoate, haloxon and paraoxon also inhibited hydrolase activity [5].
• Haloxon had little effect on malate dehydrogenase activity of any of the parasite [6].

Anatomical context of Galloxon

• In contrast, after haloxon treatment (100 mg/kg p.o.) an accumulation of microfilariae was found in the peritoneal cavity only, following a time course similar to that after DEC [7].

Associations of Galloxon with other chemical compounds

• The anthelmintic efficacy of oxfendazole and haloxon against arrested Haemonchus contortus larvae in sheep [8].
• SAN did not inhibit DAN synthesis, while HAL was a profound inhibitor of DNA synthesis (98% inhibition after 4 h at 100 microgram/ml) [9].

References