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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nematode Infections

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Disease relevance of Nematode Infections


High impact information on Nematode Infections

  • Furthermore, production of Th2 cytokines from T cells as well as IgE and IgG1 responses after nematode infection were profoundly reduced [6].
  • Our results show that the systemic secretion of RMCP II coincides with the immune expulsion of these nematodes, demonstrating clearly for the first time that rat MMC are functionally active during the immune elimination of primary nematode infections [7].
  • These results provide the first demonstration of the critical role of IL-18 in regulating Th cell responses during gastrointestinal nematode infection [8].
  • Protective immunity to nematode infection is induced by CTLA-4 blockade [9].
  • In addition, our results provide evidence that Th2-associated responses protect against, and/or Th1-associated responses exacerbate, nematode infections [10].

Chemical compound and disease context of Nematode Infections


Biological context of Nematode Infections


Anatomical context of Nematode Infections


Gene context of Nematode Infections


Analytical, diagnostic and therapeutic context of Nematode Infections


  1. IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. Blanchard, C., Durual, S., Estienne, M., Bouzakri, K., Heim, M.H., Blin, N., Cuber, J.C. J. Immunol. (2004) [Pubmed]
  2. Intestinal nematode infection ameliorates experimental colitis in mice. Khan, W.I., Blennerhasset, P.A., Varghese, A.K., Chowdhury, S.K., Omsted, P., Deng, Y., Collins, S.M. Infect. Immun. (2002) [Pubmed]
  3. Efficacy of purified schistosoma japonicum egg antigens for ELISA serodiagnosis of human Schistosomiasis japonica: specificity and sensitivity. Long, G.W., Yogore, M.G., Lewert, R.M., Blas, B.L., Pelley, R.P. Am. J. Trop. Med. Hyg. (1982) [Pubmed]
  4. Anthelmintic efficacy of febantel paste in naturally infected calves. Stuedemann, J.A., Ciordia, H., Arther, R.G. Vet. Parasitol. (1990) [Pubmed]
  5. Effect of fenbendazole molasses supplement block treatment on nematode infection and subsequent weight gain of weanling beef calves. Miller, J.E., Olson, T.A., Kearney, M.T., Myers, G.H., Williams, J.C. Vet. Parasitol. (1992) [Pubmed]
  6. Essential role of Stat6 in IL-4 signalling. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., Akira, S. Nature (1996) [Pubmed]
  7. Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rat. Woodbury, R.G., Miller, H.R., Huntley, J.F., Newlands, G.F., Palliser, A.C., Wakelin, D. Nature (1984) [Pubmed]
  8. Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13. Helmby, H., Takeda, K., Akira, S., Grencis, R.K. J. Exp. Med. (2001) [Pubmed]
  9. Protective immunity to nematode infection is induced by CTLA-4 blockade. McCoy, K., Camberis, M., Gros, G.L. J. Exp. Med. (1997) [Pubmed]
  10. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. Finkelman, F.D., Madden, K.B., Cheever, A.W., Katona, I.M., Morris, S.C., Gately, M.K., Hubbard, B.R., Gause, W.C., Urban, J.F. J. Exp. Med. (1994) [Pubmed]
  11. Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. Bennett, A., Guyatt, H. Parasitol. Today (Regul. Ed.) (2000) [Pubmed]
  12. Alterations in regional blood flow in rats following sensitization to the nematode Nippostrongylus brasiliensis: effects of PAF antagonists. Mathison, R., Rimmer, C., Davison, J.S., Wallace, J.L., Befus, A.D. Br. J. Pharmacol. (1990) [Pubmed]
  13. Alfalfa (Medicago sativa L.) resistance to the root-lesion nematode, Pratylenchus penetrans: defense-response gene mRNA and isoflavonoid phytoalexin levels in roots. Baldridge, G.D., O'Neill, N.R., Samac, D.A. Plant Mol. Biol. (1998) [Pubmed]
  14. The promoter of the nematode resistance gene Hs1pro-1 activates a nematode-responsive and feeding site-specific gene expression in sugar beet (Beta vulgaris L.) and Arabidopsis thaliana. Thurau, T., Kifle, S., Jung, C., Cai, D. Plant Mol. Biol. (2003) [Pubmed]
  15. Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice. Iraqi, F.A., Behnke, J.M., Menge, D.M., Lowe, A.M., Teale, A.J., Gibson, J.P., Baker, L.R., Wakelin, D.R. Mamm. Genome (2003) [Pubmed]
  16. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. Goodridge, H.S., Wilson, E.H., Harnett, W., Campbell, C.C., Harnett, M.M., Liew, F.Y. J. Immunol. (2001) [Pubmed]
  17. Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis. Pernthaner, A., Cole, S.A., Morrison, L., Hein, W.R. Infect. Immun. (2005) [Pubmed]
  18. Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections. Khan, W.I., Richard, M., Akiho, H., Blennerhasset, P.A., Humphreys, N.E., Grencis, R.K., Van Snick, J., Collins, S.M. Infect. Immun. (2003) [Pubmed]
  19. Modified plasma and abomasal disposition of albendazole in nematode-infected sheep. Alvarez, L.I., Sánchez, S.F., Lanusse, C.E. Vet. Parasitol. (1997) [Pubmed]
  20. IL-4- and IL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections. Mahanty, S., King, C.L., Kumaraswami, V., Regunathan, J., Maya, A., Jayaraman, K., Abrams, J.S., Ottesen, E.A., Nutman, T.B. J. Immunol. (1993) [Pubmed]
  21. Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells. Leech, M.D., Grencis, R.K. J. Immunol. (2006) [Pubmed]
  22. Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Nair, M.G., Gallagher, I.J., Taylor, M.D., Loke, P., Coulson, P.S., Wilson, R.A., Maizels, R.M., Allen, J.E. Infect. Immun. (2005) [Pubmed]
  23. Involvement of complement and fibronectin in eosinophil-mediated damage to Nippostrongylus brasiliensis larvae. Shin, E.H., Osada, Y., Sagara, H., Takatsu, K., Kojima, S. Parasite Immunol. (2001) [Pubmed]
  24. Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function. Au Yeung, K.J., Smith, A., Zhao, A., Madden, K.B., Elfrey, J., Sullivan, C., Levander, O., Urban, J.F., Shea-Donohue, T. Exp. Parasitol. (2005) [Pubmed]
  25. WSX-1: a key role in induction of chronic intestinal nematode infection. Bancroft, A.J., Humphreys, N.E., Worthington, J.J., Yoshida, H., Grencis, R.K. J. Immunol. (2004) [Pubmed]
  26. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Barner, M., Mohrs, M., Brombacher, F., Kopf, M. Curr. Biol. (1998) [Pubmed]
  27. Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Spencer, L., Shultz, L., Rajan, T.V. Infect. Immun. (2001) [Pubmed]
  28. Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection. Khan, W.I., Motomura, Y., Blennerhassett, P.A., Kanbayashi, H., Varghese, A.K., El-Sharkawy, R.T., Gauldie, J., Collins, S.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  29. Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine. Wang, M.L., Shin, M.E., Knight, P.A., Artis, D., Silberg, D.G., Suh, E., Wu, G.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  30. Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells. Akiho, H., Blennerhassett, P., Deng, Y., Collins, S.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  31. Albendazole in the treatment of intestinal helminthiasis in children. Misra, P.K., Pande, N.K., Jagota, S.C. Current medical research and opinion. (1985) [Pubmed]
  32. Evaluation of less than recommended dosages of levamisole phosphate for the treatment of gastrointestinal nematodes of cattle. Ronald, N.C., Bell, R.R., Craig, T.M. J. Am. Vet. Med. Assoc. (1977) [Pubmed]
  33. The effect of rotational grazing for periods of one or two weeks on the build-up of lungworm and gastro-intestinal nematode infections in calves. Eysker, M., Boersema, J.H., Cornelissen, J.B., Kooyman, F.N., de Leeuw, W.A., Saatkamp, H.W. The Veterinary quarterly. (1993) [Pubmed]
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