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Gene Review

mtl-2  -  Protein MTL-2

Caenorhabditis elegans

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High impact information on mtl-2

  • Cu did not induce MT1 or MT2 mRNAs [1].
  • After 10 mM Cd treatment, induction of MT1 and MT2 mRNA was three- and twofold higher, respectively, in daf-2 mutant worms than in wild-type [1].
  • Likewise, mtl-2 is not expressed in nematodes in which elt-2 has been disrupted [2].
  • Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans [3].
  • The amino acid sequence of MT-Ce is unique, and neither its putative alpha and beta domains nor its Cys residues can be readily aligned with the corresponding regions of other eukaryotic MTs [3].

Biological context of mtl-2


Associations of mtl-2 with chemical compounds


Other interactions of mtl-2

  • In vivo deletion and site-directed mutation analyses confirm that one GATA element in mtl-1 and two in mtl-2 are required for transcription [2].


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