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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

vab-3  -  Protein VAB-3

Caenorhabditis elegans

 
 
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High impact information on vab-3

  • In the nematode Caenorhabditis elegans, vab-3 mutants display many defects in head-region development, including aberrant morphogenesis, transformation of hypodermal (epidermal-like) cell fates to those of posterior homologues, and abnormal specification of neurons [1].
  • Analysis of lin-17;vab-3 double mutants suggests that vab-3 acts after lin-17 for B.a. fate specification [2].
  • We describe the function of the gene vab-3 in the B cell lineage [2].
  • Mutations in the Caenorhabditis elegans gene vab-3 reveal distinct roles in fate specification and unequal cytokinesis in an asymmetric cell division [2].
  • Four distinct types of DTC migration abnormalities were defined on the basis of the mutant phenotypes. vab-3; mig-14 double mutants exhibited the types of DTC migration defects seen for vab-3 single mutants [3].
 

Anatomical context of vab-3

  • Mutations that affect paired domain-containing isoforms cause defects in epidermal morphogenesis, epidermal cell fates, and gonad cell migration and define the class I (vab-3) complementation group [4].

References

  1. Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3. Chisholm, A.D., Horvitz, H.R. Nature (1995) [Pubmed]
  2. Mutations in the Caenorhabditis elegans gene vab-3 reveal distinct roles in fate specification and unequal cytokinesis in an asymmetric cell division. Chamberlin, H.M., Sternberg, P.W. Dev. Biol. (1995) [Pubmed]
  3. Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans. Nishiwaki, K. Genetics (1999) [Pubmed]
  4. Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms. Cinar, H.N., Chisholm, A.D. Genetics (2004) [Pubmed]
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