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PAX6  -  paired box 6

Bos taurus

 
 
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High impact information on PAX6

  • Here, we show that bovine inner cell masses from nuclear transfer and fertilized embryos, grown on feeders in serum-free medium, form polarized rosette structures expressing nestin, Pax6, Pax7, Sox1, and Otx2 and exhibiting interkinetic nuclear migration activity and cell junction distribution as in the developing neural tube [1].
  • In primates, these cells are organized into rosettes expressing Pax6 and Sox1 and are responsive to inductive signals such as Sonic hedgehog (Shh) and retinoic acid [1].
  • Alternative splicing of Pax6 in bovine eye and evolutionary conservation of intron sequences [2].
  • PAX6 expression identifies progenitor cells for corneal keratocytes [3].
  • Cytometry demonstrated PAX6 protein in 4% of freshly isolated stromal cells [3].
 

Biological context of PAX6

 

Anatomical context of PAX6

References

  1. Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro. Lazzari, G., Colleoni, S., Giannelli, S.G., Brunetti, D., Colombo, E., Lagutina, I., Galli, C., Broccoli, V. Stem Cells (2006) [Pubmed]
  2. Alternative splicing of Pax6 in bovine eye and evolutionary conservation of intron sequences. Jaworski, C., Sperbeck, S., Graham, C., Wistow, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  3. PAX6 expression identifies progenitor cells for corneal keratocytes. Funderburgh, M.L., Du, Y., Mann, M.M., SundarRaj, N., Funderburgh, J.L. FASEB J. (2005) [Pubmed]
  4. Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping. Kuiper, H., Williams, J.L., Distl, O., Drögemüller, C. Cytogenet. Genome Res. (2005) [Pubmed]
 
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