The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PAX6  -  paired box 6

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on PAX6

  • Here, we show that bovine inner cell masses from nuclear transfer and fertilized embryos, grown on feeders in serum-free medium, form polarized rosette structures expressing nestin, Pax6, Pax7, Sox1, and Otx2 and exhibiting interkinetic nuclear migration activity and cell junction distribution as in the developing neural tube [1].
  • In primates, these cells are organized into rosettes expressing Pax6 and Sox1 and are responsive to inductive signals such as Sonic hedgehog (Shh) and retinoic acid [1].
  • Alternative splicing of Pax6 in bovine eye and evolutionary conservation of intron sequences [2].
  • PAX6 expression identifies progenitor cells for corneal keratocytes [3].
  • Cytometry demonstrated PAX6 protein in 4% of freshly isolated stromal cells [3].

Biological context of PAX6


Anatomical context of PAX6


  1. Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro. Lazzari, G., Colleoni, S., Giannelli, S.G., Brunetti, D., Colombo, E., Lagutina, I., Galli, C., Broccoli, V. Stem Cells (2006) [Pubmed]
  2. Alternative splicing of Pax6 in bovine eye and evolutionary conservation of intron sequences. Jaworski, C., Sperbeck, S., Graham, C., Wistow, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  3. PAX6 expression identifies progenitor cells for corneal keratocytes. Funderburgh, M.L., Du, Y., Mann, M.M., SundarRaj, N., Funderburgh, J.L. FASEB J. (2005) [Pubmed]
  4. Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping. Kuiper, H., Williams, J.L., Distl, O., Drögemüller, C. Cytogenet. Genome Res. (2005) [Pubmed]
WikiGenes - Universities