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Gene Review

CELE_C25G6.3  -  Protein C25G6.3

Caenorhabditis elegans

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Disease relevance of luciferase

  • We describe a novel approach to assess toxicity to the free-living nematode Caenorhabditis elegans that relies on the ability of firefly luciferase to report on endogenous ATP levels [1].
  • Hybridization studies with the DNA that codes for the two subunits of luciferase revealed considerable homology among all of the strains of X. luminescens and with the DNA of other species of luminous bacteria, but none with the nonluminous Xenorhabdus species [2].

High impact information on luciferase


Chemical compound and disease context of luciferase


Biological context of luciferase


Anatomical context of luciferase


Associations of luciferase with chemical compounds


  1. Development and application of bioluminescent Caenorhabditis elegans as multicellular eukaryotic biosensors. Lagido, C., Pettitt, J., Porter, A.J., Paton, G.I., Glover, L.A. FEBS Lett. (2001) [Pubmed]
  2. Cloning, organization, and expression of the bioluminescence genes of Xenorhabdus luminescens. Frackman, S., Anhalt, M., Nealson, K.H. J. Bacteriol. (1990) [Pubmed]
  3. The transcription factor regulatory factor X1 increases the expression of neuronal glutamate transporter type 3. Ma, K., Zheng, S., Zuo, Z. J. Biol. Chem. (2006) [Pubmed]
  4. Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. Kanamoto, T., Terada, K., Yoshikawa, H., Furukawa, T. Dev. Dyn. (2006) [Pubmed]
  5. Mitochondrial complex I function affects halothane sensitivity in Caenorhabditis elegans. Kayser, E.B., Morgan, P.G., Sedensky, M.M. Anesthesiology (2004) [Pubmed]
  6. Genomic structure of the human NLK (nemo-like kinase) gene and analysis of its promoter region. Harada, H., Yoshida, S., Nobe, Y., Ezura, Y., Atake, T., Koguchi, T., Emi, M. Gene (2002) [Pubmed]
  7. Toxicity of the bacterial luciferase substrate, n-decyl aldehyde, to Saccharomyces cerevisiae and Caenorhabditis elegans. Hollis, R.P., Lagido, C., Pettitt, J., Porter, A.J., Killham, K., Paton, G.I., Glover, L.A. FEBS Lett. (2001) [Pubmed]
  8. Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. Liu, C.Z., Yang, J.T., Yoon, J.W., Villavicencio, E., Pfendler, K., Walterhouse, D., Iannaccone, P. Gene (1998) [Pubmed]
  9. Identification of 5'-upstream region of pufferfish ribosomal protein L29 gene as a strong constitutive promoter to drive GFP expression in zebrafish. Chang, M.H., Chou, C.M., Hsieh, Y.C., Lu, I.C., Devi, M.K., Chang, J.P., Kuo, T.F., Huang, C.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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