Disease relevance of Xenorhabdus

• The lux genes of Xenorhabdus luminescens, a symbiont of the nematode Heterorhabditis bacteriophora, were cloned and expressed in Escherichia coli [1].
• Xenorhabdus nematophilus (three strains), Xenorhabdus bovienii (one strain), and Photorhabdus luminescens (one strain) showed both exo- and endochitinase activity using p-nitrophenyl-N-acetyl-beta-D-glucosaminide and p-nitrophenyl-beta-D-N,N',N'-triacetylchitotriose, respectively, as substrates [2].
• Morganella morganii, Tatumella ptyseos and all species of Xenorhabdus and Providencia (as defined by DNA relatedness studies) showed little or no PEP phosphorylation of alpha-methyl-D-glucoside, suggesting the absence of the IIGlc entry route (group III organisms) [3].

High impact information on Xenorhabdus

• Molecular analysis of the two-component genes, ompR and envZ, in the symbiotic bacterium Xenorhabdus nematophilus [4].
• The mode of action of 3,5-dihydroxy-4-ethyl-trans-stilbene (ES), an antibiotic produced by Xenorhabdus luminescens symbiotically associated with an entomopathogenic nematode, was investigated [5].
• Pyrimidine nucleoside salvage confers an advantage to Xenorhabdus nematophila in its host interactions [6].
• Identification and functional characterization of a Xenorhabdus nematophila oligopeptide permease [7].
• We show that inactivation of envZ, the gene encoding the histidine kinase sensor protein, EnvZ, of Xenorhabdus nematophilus, affected the production of several outer membrane proteins (Opns) [8].

Chemical compound and disease context of Xenorhabdus

• Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens [9].
• We have investigated the interactions of a recombinant luciferase from a terrestrial bacterium Xenorhabdus luminescens with the reaction products, FMN and myristic acid, using steady-state fluorescence spectroscopy [10].
• We investigated the fatty acid composition of Xenorhabdus species when grown at 15, 20, 25 or 30 degrees C on media containing one of two primary carbon sources: glucose or lipids from the insect host, Galleria mellonella [11].
• Identification of an antibacterial compound, benzylideneacetone, from Xenorhabdus nematophila against major plant-pathogenic bacteria [12].
• Antimicrobial activity and biosynthesis of indole antibiotics produced by Xenorhabdus nematophilus [13].

Biological context of Xenorhabdus

• Cloning and nucleotide sequences of lux genes and characterization of luciferase of Xenorhabdus luminescens from a human wound [14].
• Three strains of Xenorhabdus nematophilus (A24, F1, NC116) and strain Dan of Xenorhabdus bovienii were tested to evaluate whether the phase variation observed in these bacteria was in any way connected with plasmids [15].

Gene context of Xenorhabdus

• Cloning and nucleotide sequence of a flagellin encoding genetic locus from Xenorhabdus nematophilus: phase variation leads to differential transcription of two flagellar genes (fliCD) [16].
• Hybridization studies with the DNA that codes for the two subunits of luciferase revealed considerable homology among all of the strains of X. luminescens and with the DNA of other species of luminous bacteria, but none with the nonluminous Xenorhabdus species [1].
• Cloning and heterologous expression of a novel insecticidal gene (tccC1) from Xenorhabdus nematophilus strain [17].
• To determine whether RecA-mediated processes are linked to phase variation, the recA gene of Xenorhabdus bovienii was cloned and sequenced [18].
• These latter results suggest that a gene(s) higher in the transcriptional hierarchy of the flagellar regulon is switched off in Xenorhabdus phase II variants [16].

Analytical, diagnostic and therapeutic context of Xenorhabdus

• Immobilization of Escherichia coli expressing the lux genes of Xenorhabdus luminescens [19].
• Molecular cloning and characterization of the lux genes from the secondary form of Xenorhabdus luminescens, K122 [20].

References