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Gene Review

Ott  -  ovary testis transcribed

Mus musculus

Synonyms: AV272316
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Disease relevance of Ott

  • This work could lead to the identification of a human Ott homologue, which is likely to be X-linked and would provide a candidate locus for some cases of male infertility [1].
  • The optic disk-directed growth of retinal ganglion cell axons is markedly disturbed in the presence of polyclonal antineurolin antibodies, which mildly affect fasciculation (Ott, H., M. Bastmeyer, and C.A.O. Stuermer, 1998. J. Neurosci. 18:3363-3372) [2].

High impact information on Ott

  • At least seven Ott genes are transcribed specifically during meiosis and are predicted to encode "pioneer' proteins with an unusual structure, containing tandem arrays of a degenerate eight amino acid repeat [1].
  • Ott, a mouse X-linked multigene family expressed specifically during meiosis [1].
  • Steady-state levels of a 2.3 kb polyadenylated Ott mRNA are high throughout meiotic prophase in the testis when the X chromosome is generally transcriptionally inactive [1].
  • Capacitative Ca(2+) entry stimulates cAMP synthesis in mouse parotid acini, suggesting that one of the Ca(2+)-sensitive adenylyl cyclases (AC1 or AC8) may play an important role in the regulation of parotid function (Watson, E. L., Wu, Z., Jacobson, K. L., Storm, D. R., Singh, J. C., and Ott, S. M. (1998) Am. J. Physiol. 274, C557-C565) [3].


  1. Ott, a mouse X-linked multigene family expressed specifically during meiosis. Kerr, S.M., Taggart, M.H., Lee, M., Cooke, H.J. Hum. Mol. Genet. (1996) [Pubmed]
  2. Neurolin Ig domain 2 participates in retinal axon guidance and Ig domains 1 and 3 in fasciculation. Leppert, C.A., Diekmann, H., Paul, C., Laessing, U., Marx, M., Bastmeyer, M., Stuermer, C.A. J. Cell Biol. (1999) [Pubmed]
  3. The type 8 adenylyl cyclase is critical for Ca2+ stimulation of cAMP accumulation in mouse parotid acini. Watson, E.L., Jacobson, K.L., Singh, J.C., Idzerda, R., Ott, S.M., DiJulio, D.H., Wong, S.T., Storm, D.R. J. Biol. Chem. (2000) [Pubmed]
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