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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nuclear Magnetic Resonance, Biomolecular

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Disease relevance of Nuclear Magnetic Resonance, Biomolecular


High impact information on Nuclear Magnetic Resonance, Biomolecular

  • A two-dimensional heteronuclear nuclear magnetic resonance (NMR) spectrum was recorded after the rapid initiation of the refolding of a protein labeled with nitrogen-15 [6].
  • We have determined the three-dimensional structure of the UvrC CTD using heteronuclear NMR techniques [7].
  • We have determined the solution structure of the MBD of the human methylation-dependent transcriptional repressor MBD1 by multi-dimensional heteronuclear NMR spectroscopy [8].
  • We have determined the solution structure of the C-terminal SH2 domain of the p85 alpha subunit of human phosphatidylinositol (PI) 3-kinase (EC in complex with a phosphorylated tyrosine pentapeptide sequence from the platelet-derived growth factor receptor using heteronuclear nuclear magnetic resonance spectroscopy [9].
  • Using multidimensional heteronuclear NMR, we have mapped intermolecular contacts between the human U1A protein 102 amino acid N-terminal RNP domain and a 31-mer oligonucleotide derived from stem-loop II of U1 snRNA [10].

Chemical compound and disease context of Nuclear Magnetic Resonance, Biomolecular


Biological context of Nuclear Magnetic Resonance, Biomolecular


Anatomical context of Nuclear Magnetic Resonance, Biomolecular


Associations of Nuclear Magnetic Resonance, Biomolecular with chemical compounds


Gene context of Nuclear Magnetic Resonance, Biomolecular

  • Each was then synthetically prepared, its structure confirmed by multinuclear NMR and high resolution mass spectrometry, and shown to possess identical CD36 binding activity and LC/ESI/MS/MS characteristics in both native and derivatized forms [31].
  • The three-dimensional solution structure of the core globular domain of the C-terminal region of Ku86 (Ku86CTR(592-709)) has been determined using heteronuclear NMR spectroscopy and dynamical simulated annealing using structural restraints from nuclear Overhauser effect spectroscopy, and scalar and residual dipolar couplings [32].
  • We have determined the tertiary structure of human prolactin using three-dimensional (3D) and four-dimensional (4D) heteronuclear NMR spectroscopy [33].
  • The three-dimensional structure and backbone dynamics of a truncated and multiply substituted recombinant human interleukin-3 (IL-3) variant (SC-65369) have been determined from multidimensional heteronuclear nuclear magnetic resonance spectroscopic data [34].
  • Recombinant murine LIF was studied by multidimensional homonuclear and 1H-15N heteronuclear NMR and 95% of backbone amide resonances assigned [35].

Analytical, diagnostic and therapeutic context of Nuclear Magnetic Resonance, Biomolecular


  1. Overproduction and one-step purification of Escherichia coli 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase and oxygen transfer studies during catalysis using isotopic-shifted heteronuclear NMR. Dotson, G.D., Dua, R.K., Clemens, J.C., Wooten, E.W., Woodard, R.W. J. Biol. Chem. (1995) [Pubmed]
  2. Is the structure of the N-domain of phosphoglycerate kinase affected by isolation from the intact molecule? Hosszu, L.L., Craven, C.J., Spencer, J., Parker, M.J., Clarke, A.R., Kelly, M., Waltho, J.P. Biochemistry (1997) [Pubmed]
  3. Determination by heteronuclear NMR spectroscopy of the complete structure of the cell wall polysaccharide of Streptococcus sanguis strain K103. Reddy, G.P., Chang, C.C., Bush, C.A. Anal. Chem. (1993) [Pubmed]
  4. Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., Mullen, G.P. Biochemistry (1996) [Pubmed]
  5. Unusual helix-containing greek keys in development-specific Ca(2+)-binding protein S. 1H, 15N, and 13C assignments and secondary structure determined with the use of multidimensional double and triple resonance heteronuclear NMR spectroscopy. Bagby, S., Harvey, T.S., Kay, L.E., Eagle, S.G., Inouye, S., Ikura, M. Biochemistry (1994) [Pubmed]
  6. Protein folding monitored at individual residues during a two-dimensional NMR experiment. Balbach, J., Forge, V., Lau, W.S., van Nuland, N.A., Brew, K., Dobson, C.M. Science (1996) [Pubmed]
  7. Solution structure and DNA-binding properties of the C-terminal domain of UvrC from E.coli. Singh, S., Folkers, G.E., Bonvin, A.M., Boelens, R., Wechselberger, R., Niztayev, A., Kaptein, R. EMBO J. (2002) [Pubmed]
  8. Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1. Ohki, I., Shimotake, N., Fujita, N., Nakao, M., Shirakawa, M. EMBO J. (1999) [Pubmed]
  9. Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. Breeze, A.L., Kara, B.V., Barratt, D.G., Anderson, M., Smith, J.C., Luke, R.W., Best, J.R., Cartlidge, S.A. EMBO J. (1996) [Pubmed]
  10. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. Howe, P.W., Nagai, K., Neuhaus, D., Varani, G. EMBO J. (1994) [Pubmed]
  11. Phosphotransfer and CheY-binding domains of the histidine autokinase CheA are joined by a flexible linker. Zhou, H., McEvoy, M.M., Lowry, D.F., Swanson, R.V., Simon, M.I., Dahlquist, F.W. Biochemistry (1996) [Pubmed]
  12. Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2. Drohat, A.C., Stivers, J.T. Biochemistry (2000) [Pubmed]
  13. Initial analysis of 750 MHz NMR spectra of selective 15N-G,U labelled E. coli 5S rRNA. Grüne, M., Görlach, M., Soskic, V., Klussmann, S., Bald, R., Fürste, J.P., Erdmann, V.A., Brown, L.R. FEBS Lett. (1996) [Pubmed]
  14. Heteronuclear NMR studies of the specificity of the post-translational modification of biotinyl domains by biotinyl protein ligase. Reche, P.A., Howard, M.J., Broadhurst, R.W., Perham, R.N. FEBS Lett. (2000) [Pubmed]
  15. Synthesis, spectroscopy (IR, multinuclear NMR, ESI-MS), diffraction, density functional study and in vitro antiproliferative activity of pyrazole-beta-diketone dihalotin(IV) compounds on 5 melanoma cell lines. Pettinari, C., Caruso, F., Zaffaroni, N., Villa, R., Marchetti, F., Pettinari, R., Phillips, C., Tanski, J., Rossi, M. J. Inorg. Biochem. (2006) [Pubmed]
  16. Identification of the ribosome binding sites of translation initiation factor IF3 by multidimensional heteronuclear NMR spectroscopy. Sette, M., Spurio, R., van Tilborg, P., Gualerzi, C.O., Boelens, R. RNA (1999) [Pubmed]
  17. Secondary structure and fold homology of the ArsC protein from the Escherichia coli arsenic resistance plasmid R773. Stevens, S.Y., Hu, W., Gladysheva, T., Rosen, B.P., Zuiderweg, E.R., Lee, L. Biochemistry (1999) [Pubmed]
  18. Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex. Yan, H., Liao, X. Biophys. J. (2003) [Pubmed]
  19. Ion transport by lasalocid A across red-blood-cell membranes. A multinuclear NMR study. Fernandez, E., Grandjean, J., Laszlo, P. Eur. J. Biochem. (1987) [Pubmed]
  20. The structure of a glycerol teichoic acid-like O-specific polysaccharide of Hafnia alvei 1205. Katzenellenbogen, E., Romanowska, E., Kocharova, N.A., Knirel, Y.A., Shashkov, A.S., Kochetkov, N.K. Carbohydr. Res. (1992) [Pubmed]
  21. Conformation and dynamics of ribosomal stalk protein L12 in solution and on the ribosome. Mulder, F.A., Bouakaz, L., Lundell, A., Venkataramana, M., Liljas, A., Akke, M., Sanyal, S. Biochemistry (2004) [Pubmed]
  22. Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution. Werner, J.M., Breeze, A.L., Kara, B., Rosenbrock, G., Boyd, J., Soffe, N., Campbell, I.D. Biochemistry (1994) [Pubmed]
  23. The high-resolution, three-dimensional solution structure of human interleukin-4 determined by multidimensional heteronuclear magnetic resonance spectroscopy. Powers, R., Garrett, D.S., March, C.J., Frieden, E.A., Gronenborn, A.M., Clore, G.M. Biochemistry (1993) [Pubmed]
  24. A multinuclear NMR study of 2,3-bisphosphoglycerate metabolism in the human erythrocyte. Oxley, S.T., Porteous, R., Brindle, K.M., Boyd, J., Campbell, I.D. Biochim. Biophys. Acta (1984) [Pubmed]
  25. Response of 3T3 cells on stimulation of adenylate cyclase by forskolin, studied by multinuclear NMR spectroscopy. Flögel, U., Leibfritz, D. Biol. Chem. Hoppe-Seyler (1993) [Pubmed]
  26. Characterization of covalent adriamycin-DNA adducts. Zeman, S.M., Phillips, D.R., Crothers, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. Garton, N.J., Gilleron, M., Brando, T., Dan, H.H., Giguère, S., Puzo, G., Prescott, J.F., Sutcliffe, I.C. J. Biol. Chem. (2002) [Pubmed]
  28. Roles of aromatic residues in the structure and biological activity of the small cytokine, growth-blocking peptide (GBP). Tada, M., Aizawa, T., Shinohara, Y., Matsubara, K., Miura, K., Yoshida, M., Shitara, K., Kouno, T., Mizuguchi, M., Nitta, K., Hayakawa, Y., Kawano, K. J. Biol. Chem. (2003) [Pubmed]
  29. A multinuclear NMR study of the interactions of cations with proteoglycans, heparin, and Ficoll. Lerner, L., Torchia, D.A. J. Biol. Chem. (1986) [Pubmed]
  30. Expression and secondary structure determination by NMR methods of the major house dust mite allergen Der p 2. Mueller, G.A., Smith, A.M., Williams, D.C., Hakkaart, G.A., Aalberse, R.C., Chapman, M.D., Rule, G.S., Benjamin, D.C. J. Biol. Chem. (1997) [Pubmed]
  31. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. Podrez, E.A., Poliakov, E., Shen, Z., Zhang, R., Deng, Y., Sun, M., Finton, P.J., Shan, L., Gugiu, B., Fox, P.L., Hoff, H.F., Salomon, R.G., Hazen, S.L. J. Biol. Chem. (2002) [Pubmed]
  32. The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). Harris, R., Esposito, D., Sankar, A., Maman, J.D., Hinks, J.A., Pearl, L.H., Driscoll, P.C. J. Mol. Biol. (2004) [Pubmed]
  33. The tertiary structure and backbone dynamics of human prolactin. Keeler, C., Dannies, P.S., Hodsdon, M.E. J. Mol. Biol. (2003) [Pubmed]
  34. Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. Feng, Y., Klein, B.K., McWherter, C.A. J. Mol. Biol. (1996) [Pubmed]
  35. Solution dynamics and secondary structure of murine leukemia inhibitory factor: a four-helix cytokine with a rigid CD loop. Purvis, D.H., Mabbutt, B.C. Biochemistry (1997) [Pubmed]
  36. Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase. Drohat, A.C., Jagadeesh, J., Ferguson, E., Stivers, J.T. Biochemistry (1999) [Pubmed]
  37. NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate. MacRaild, C.A., Hatters, D.M., Howlett, G.J., Gooley, P.R. Biochemistry (2001) [Pubmed]
  38. Relationship between electrostatics and redox function in human thioredoxin: characterization of pH titration shifts using two-dimensional homo- and heteronuclear NMR. Forman-Kay, J.D., Clore, G.M., Gronenborn, A.M. Biochemistry (1992) [Pubmed]
  39. Synthesis, characterization, and photochemical behavior of {Ru(arene)}2+ derivatives of alpha-[PW11O39]7-: an organometallic way to ruthenium-substituted heteropolytungstates. Artero, V., Laurencin, D., Villanneau, R., Thouvenot, R., Herson, P., Gouzerh, P., Proust, A. Inorganic chemistry. (2005) [Pubmed]
  40. Synthetic, spectral, thermal and antimicrobial studies on some mixed 1,3-dithia-2-stannacyclopentane derivatives with dialkyldithiocarbamates. Chauhan, H.P., Shaik, N.M. J. Inorg. Biochem. (2005) [Pubmed]
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