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Gene Review

SLC35A2  -  solute carrier family 35 (UDP-galactose...

Canis lupus familiaris

Synonyms: UDP-Gal-Tr, UGT
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High impact information on SLC35A2

  • (ii) Compared to the corresponding human tissues, canine 3-O- and 6-O-morphine UGT activities were found to be >10-fold higher in dog liver and ca. 10-fold lower in small intestinal microsomes [1].
  • Small intestinal morphine and 4-hydroxybiphenyl UGT activities appeared to be moderately (2- to 3-fold) induced by oral treatment with BNF [1].
  • (iii) In contrast to dogs, morphine UGT activities were found to be similar in homogenates from human enterocytes and liver [1].
  • Dog UGTs were investigated in comparison with related human UGTs by examples, (i) expression of dog UGT1A6, the first sequenced dog phenol UGT, and (ii) morphine UGT activities, responsible for intestinal and hepatic first-pass metabolism of morphine [1].
  • We identified human UDP-glucuronosyltransferase (UGT) isoforms responsible for producing dihydrotestosterone (DHT) diglucuronide, a novel glucuronide in which the second glucuronosyl moiety is attached at the C2' position of the first glucuronosyl moiety, leading to diglucuronosyl conjugation of a single hydroxyl group of DHT at the C17 position [2].

Biological context of SLC35A2


Anatomical context of SLC35A2

  • Results obtained with the new assay confirmed the previously reported rank order of glucuronidation velocity of several typical UGT substrates and the finding that the glucuronidation of most of these compounds is significantly faster in dog than in human liver microsomes [4].
  • Despite being lower than fresh cells, UGT activity in dog CP hepatocytes did not decrease from 0 to 24 hours of culture [5].

Associations of SLC35A2 with chemical compounds

  • The assay was validated with 15 structurally diverse UGT substrates containing acidic, phenolic, and hydroxyl reacting groups [4].
  • It is unclear which family members of human UDP-glucuronosyltransferases (UGT) are involved in the formation of the glucuronide [6].
  • O-Glucuronidation of 5-hydroxyrofecoxib by human liver microsomes and eight cDNA-expressed human UGT isoforms were investigated [6].
  • The objective of this study was to identify the isoform(s) of human liver and intestinal UDP-glucuronosyltransferase (UGT) enzymes responsible for the glucuronidation of ezetimibe [7].
  • The effects of detergents were also investigated with dog liver microsomes, and Brij 35 and Brij 58 were found to be the best detergents to use for maximal activation of the dog liver morphine UGT [8].

Analytical, diagnostic and therapeutic context of SLC35A2


  1. Tissue-specific regulation of canine intestinal and hepatic phenol and morphine UDP-glucuronosyltransferases by beta-naphthoflavone in comparison with humans. Bock, K.W., Bock-Hennig, B.S., Münzel, P.A., Brandenburg, J.O., Köhle, C.T., Soars, M.G., Riley, R.J., Burchell, B., Richter, O., Eichelbaum, M.F., Swedmark, S., Orzechowski, A. Biochem. Pharmacol. (2002) [Pubmed]
  2. Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide. Murai, T., Samata, N., Iwabuchi, H., Ikeda, T. Drug Metab. Dispos. (2006) [Pubmed]
  3. Purification of a phenobarbital-inducible UDP-glucuronosyltransferase isoform from dog liver which catalyzes morphine and testosterone glucuronidation. Oguri, K., Kurogi, A., Yamabe, K., Tanaka, M., Yoshisue, K., Ishii, Y., Yoshimura, H. Arch. Biochem. Biophys. (1996) [Pubmed]
  4. Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay. Di Marco, A., D'Antoni, M., Attaccalite, S., Carotenuto, P., Laufer, R. Drug Metab. Dispos. (2005) [Pubmed]
  5. Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures. Hewitt, N.J., Utesch, D. Human & experimental toxicology. (2004) [Pubmed]
  6. Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism. Zhang, J.Y., Zhan, J., Cook, C.S., Ings, R.M., Breau, A.P. Drug Metab. Dispos. (2003) [Pubmed]
  7. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia). Ghosal, A., Hapangama, N., Yuan, Y., Achanfuo-Yeboah, J., Iannucci, R., Chowdhury, S., Alton, K., Patrick, J.E., Zbaida, S. Drug Metab. Dispos. (2004) [Pubmed]
  8. The glucuronidation of morphine by dog liver microsomes: identification of morphine-6-O-glucuronide. King, C., Finley, B., Franklin, R. Drug Metab. Dispos. (2000) [Pubmed]
  9. Cloning and characterization of a canine UDP-glucuronosyltransferase. Soars, M.G., Smith, D.J., Riley, R.J., Burchell, B. Arch. Biochem. Biophys. (2001) [Pubmed]
  10. Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6. Court, M.H. J. Vet. Pharmacol. Ther. (2001) [Pubmed]
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