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Prkci  -  protein kinase C, iota

Mus musculus

Synonyms: 2310021H13Rik, AI427505, Atypical protein kinase C-lambda/iota, PKClambda, Pkci, ...
 
 
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High impact information on Prkci

  • In spite of the loss of adherens junctions in the neuroepithelium of conditional aPKClambda knockout mice, neurons were produced at a normal rate [1].
  • In conditional aPKClambda knockout mice, neuroepithelial cells of the neocortical region lost aPKClambda protein at embryonic day 15 and demonstrated a loss of adherens junctions, retraction of apical processes and impaired interkinetic nuclear migration that resulted in disordered neuroepithelial tissue architecture [1].
  • These persistent spot-like AJs in aPKClambda-expressing cells contain all TJ membrane proteins and PAR-3, indicating that aPKC kinase activity is not required for their translocation to these premature junctional complexes but is indispensable for their further differentiation into belt-like AJs and TJs [2].
  • Immunofluorescence analysis revealed that PAR-3 and aPKClambda translocate to cell-cell contact regions later than the formation of the primordial spot-like adherens junctions (AJs) containing E-cadherin and ZO-1 [2].
  • Consistently, the expression of a dominant-negative mutant of aPKClambda (aPKClambdakn) in wound healing cells does not inhibit the formation of the spot-like AJs; rather, it blocks their development into belt-like AJs [2].
 

Anatomical context of Prkci

  • These results indicate that the expression of aPKClambda in differentiating photoreceptors is required for total retinal lamination [3].
 

Other interactions of Prkci

 

Analytical, diagnostic and therapeutic context of Prkci

  • To elucidate the functions of aPKClambda, one out of two aPKC members, in mouse neocortical neurogenesis, a Nestin-Cre mediated conditional gene targeting system was employed [1].

References

  1. Inactivation of aPKC{lambda} results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Imai, F., Hirai, S., Akimoto, K., Koyama, H., Miyata, T., Ogawa, M., Noguchi, S., Sasaoka, T., Noda, T., Ohno, S. Development (2006) [Pubmed]
  2. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K., Ohno, S. J. Cell. Sci. (2002) [Pubmed]
  3. Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. Koike, C., Nishida, A., Akimoto, K., Nakaya, M.A., Noda, T., Ohno, S., Furukawa, T. J. Neurosci. (2005) [Pubmed]
 
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